Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewDonitriptan hydrochloride
说明： 5-HT1B/1D agonist
化学名： 1-[[[3-(2-Aminoethyl)-1H-indol-5-yl]oxy]acetyl]-4-(4-cyanophenyl)-piperazine hydrochloride
纯度： ≥98% (HPLC)
生物活性 for Donitriptan hydrochloride
Brain penetrant 5-HT1B/1D agonist (pKi values are 9.3 and 9.4 for 5-HT1D and 5-HT1B respectively). Inhibits capsaicin-induced external carotid vasodilation and produces selective carotid vasoconstriction in various animal species. Displays antimigraine activity.
技术数据 for Donitriptan hydrochloride
| 分子量 | 439.94 |
| 公式 | C23H25N5O2.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 170911-68-9 |
| PubChem ID | 197705 |
| InChI Key | ZXENQGQAPOYDOJ-UHFFFAOYSA-N |
| Smiles | NCCC2=CNC1=CC=C(OCC(N3CCN(C4=CC=C(C#N)C=C4)CC3)=O)C=C12.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Donitriptan hydrochloride
参考文献 for Donitriptan hydrochloride
参考文献是支持产品生物活性的出版物。
Letienne et al (2003) Donitriptan selectively decreases jugular venous oxygen saturation in the anesthetized pig: further insights into its mechanism of action relevant to headache relief. J.Pharmacol.Exp.Ther. 305 749 PMID: 12606602
Letienne et al (2005) Donitriptan decreases jugular venous oxygen saturation in rats in the absence of cranial vasoconstriction: an overlooked mechanism of antimigraine action? J.Pharmacol.Exp.Ther. 315 849 PMID: 16027226
Munoz-Islas et al (2006) Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilation via 5-HT1B rather than 5-HT1D receptors. Br.J.Pharmacol. 149 82 PMID: 16880765
按产品操作查看相关产品
关键词: Donitriptan hydrochloride, Donitriptan hydrochloride supplier, serotonin, 5-HT1B, 5-HT1D, 5-HT1B/1D, receptors, agonists, Receptors, 3665, Tocris Bioscience
Donitriptan hydrochloride 的评论
目前没有该产品的评论。 Be the first to review Donitriptan hydrochloride and earn rewards!
Have you used Donitriptan hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.