主页 / 细胞生物学 / Regulated Cell Death / Apoptosis / Apoptosis Inducers / CFM 4

CFM 4

Cat. No. 5144 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5144 has been discontinued.

View all Apoptosis Inducers products.
说明： CARP-1 mimetic; proapoptotic
化学名： 1-[(2-Chlorophenyl)methyl]-5'-phenyl-spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one
纯度： ≥99% (HPLC)
说明书
引用文献
评论
文献 (1)
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for CFM 4

CFM 4 is a CARP-1 mimetic; interferes with CARP-1 binding to APC-2. Enhances CARP-1 expression and induces G2/M cell cycle arrest. Induces apoptosis and suppresses cell growth in cancer cells.

技术数据 for CFM 4

分子量 405.9
公式 C22H16ClN3OS
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 331458-02-7
PubChem ID 2871439
InChI Key PMADITKBVODKSF-UHFFFAOYSA-N
Smiles O=C2N(CC4=CC=CC=C4Cl)C1=CC=CC=C1C32NN=C(C5=CC=CC=C5)S3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for CFM 4

参考文献是支持产品生物活性的出版物。

Puliyappadamba et al (2011) Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis. J.Biol.Chem. 286 38000 PMID: 21903591

Ashour et al (2013) CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth. PLoS ONE 8 e66733 PMID: 23826121

按标靶查看相关产品

关键词: CFM 4, CFM 4 supplier, CFM4, CARP-1, mimetic, proapoptotic, antitumor, antitumorgenic, APC-2, G2M, cell, cycle, arrest, Apoptosis, Inducers, Cell, Cycle, Inhibitors, 5144, Tocris Bioscience

篇 CFM 4 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 CFM 4 的引用文献。

CFM 4 的评论

目前没有该产品的评论。 Be the first to review CFM 4 and earn rewards!

Have you used CFM 4?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for CFM 4

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.