Bromocriptine mesylate

Pricing Availability   Qty

15% Off Limited-time Savings on Your Reagents, Assays, and Kits
Now through September 27th, you can save 15% on Bio-Techne reagents, assays, and kits (including Novus, Tocris, and R&D Systems). Use promotion code SAVE15 at checkout on orders over $1,000. See terms and conditions for offer details.

Cat.No. 0427 - Bromocriptine mesylate | C32H40BrN5O5.CH3SO3H | CAS No. 22260-51-1
说明: D2-like agonist (D2>D3>D4)
化学名: (5'a)-2-Bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)ergotaman-3',6',18-trione mesylate
纯度: ≥98% (HPLC)
引用文献 (3)
文献 (5)

生物活性 for Bromocriptine mesylate

Bromocriptine mesylate is a selective D3 and D2 dopamine receptor agonist (Ki values are ~ 5 nM and ~ 8 nM respectively). Activates both isoforms of D2 receptor (EC50 values are 0.10-0.12 nM and 4.4 nM for D2L and D2S receptors, respectively. Bromocriptine shows anti-Aβ effects that are increased in combination with Cromolyn (Cat. No. 6424) and Topiramate (Cat. No. 3620). Also lowers glucose and increases insulin sensitivity in vivo.

化合物库 for Bromocriptine mesylate

Bromocriptine mesylate is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Bromocriptine mesylate

分子量 750.7
公式 C32H40BrN5O5.CH3SO3H
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 22260-51-1
PubChem ID 31100
Smiles [H][C@]4([C@@](N[C@]([C@H](C)C)5C(N([C@@]([H])(CC(C)C)C(N(CCC7)[C@@]76[H])=O)[C@@]6(O)O5)=O)=O)CN([C@](C3=C4)([H])CC1=C(Br)NC2=C1C3=CC=C2)C.CS(=O)(O)=O


Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Bromocriptine mesylate

溶剂 最高浓度 mg/mL 最高浓度 mM
DMSO 75.07 100

制备储备液 for Bromocriptine mesylate

以下数据基于产品分子量 750.7。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.33 mL 6.66 mL 13.32 mL
5 mM 0.27 mL 1.33 mL 2.66 mL
10 mM 0.13 mL 0.67 mL 1.33 mL
50 mM 0.03 mL 0.13 mL 0.27 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

产品说明书 for Bromocriptine mesylate


参考文献 for Bromocriptine mesylate


Aubner et al (1990) Bromocriptine produces decreases in cocaine self-administration in the rat. Neuropsychopharmacology 3 101 PMID: 2317262

Lieberman and Goldstein (1985) Bromocriptine in Parkinson disease. Pharmacol.Rev. 37 217 PMID: 3901046

Seeman and Van Tol (1994) DA receptor pharmacology. TiPS 15 264 PMID: 7940991

Traub et al (1985) The effects of chronic bromocri. treatment on behaviour and DA receptor binding in the rat striatum. Eur.J.Pharmacol. 118 147 PMID: 3936723

Kondo et al (2017) iPSC-based compound screening and in vitro trials identify a synergistic anti-amyloid β combination for Alzheimer's disease. Cell Rep. 21 2304 PMID: 29166618

Tavares et al (2021) Dopamine D2 receptor agonist, bromocriptine, remodels adipose tissue dopaminergic signalling and upregulates catabolic pathways, improving metabolic profile in type 2 diabetes. Mol.Metab. 51 101241 PMID: 33933677

If you know of a relevant reference for Bromocriptine mesylate, please let us know.


查看全部 Non-selective Dopamine Agonists

关键词: Bromocriptine mesylate, Bromocriptine mesylate supplier, Selective, D2-like, agonists, Dopamine, Non-Selective, Receptors, D3, D4, dopaminergic, insulin, glucose, Ab, Abeta, amyloid, alzheimers, antidiabetic, Non-selective, Amyloid, Beta, Peptides, 0427, Tocris Bioscience

3 篇 Bromocriptine mesylate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Bromocriptine mesylate 的部分引用包括:

Pedersen et al (2021) A novel luminescence-based-β-arrestin recruitment assay for unmodified receptors. J Biol Chem 296 100503 PMID: 33684444

Liberante et al (2016) Identification and validation of the DA agonist bromocri. as a novel therapy for high-risk myelodysplastic syndromes and secondary acute myeloid leukemia. Oncotarget 7 6609 PMID: 26735888

Jia et al (2013) Age-dependent regulation of synaptic connections by DA D2 receptors. Nat Neurosci 16 1627 PMID: 24121738

您是否知道使用了 Tocris Bromocriptine mesylate 的优秀论文? 请告知我们.

Bromocriptine mesylate 的评论

目前没有该产品的评论。 Be the first to review Bromocriptine mesylate and earn rewards!

Have you used Bromocriptine mesylate?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review


Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意,Tocris 仅会向正规科研企业/机构地址发送文献。

GPCR Product Listing

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Neurodegeneration Product Guide

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Parkinson's Poster

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Schizophrenia Poster

Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.