Bromocriptine mesylate

Pricing Availability   Qty
Cat.No. 0427 - Bromocriptine mesylate | C32H40BrN5O5.CH3SO3H | CAS No. 22260-51-1
说明: D2-like agonist (D2>D3>D4)
化学名: (5'a)-2-Bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)ergotaman-3',6',18-trione mesylate
纯度: ≥98% (HPLC)
说明书
引用文献 (3)
评论
文献 (5)

生物活性 for Bromocriptine mesylate

Bromocriptine mesylate is a selective D2-like dopamine receptor agonist (Ki values are ~ 8, ~ 5, ~ 290, ~ 440 and ~ 450 nM for D2, D3, D4, D1 and D5 receptors respectively).

化合物库 for Bromocriptine mesylate

Bromocriptine mesylate is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Bromocriptine mesylate

分子量 750.7
公式 C32H40BrN5O5.CH3SO3H
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 22260-51-1
PubChem ID 31100
InChI Key NOJMTMIRQRDZMT-GSPXQYRGSA-N
Smiles [H][C@]4([C@@](N[C@]([C@H](C)C)5C(N([C@@]([H])(CC(C)C)C(N(CCC7)[C@@]76[H])=O)[C@@]6(O)O5)=O)=O)CN([C@](C3=C4)([H])CC1=C(Br)NC2=C1C3=CC=C2)C.CS(=O)(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Bromocriptine mesylate

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 7.51 10
DMSO 75.07 100

制备储备液 for Bromocriptine mesylate

以下数据基于产品分子量 750.7。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.33 mL 6.66 mL 13.32 mL
5 mM 0.27 mL 1.33 mL 2.66 mL
10 mM 0.13 mL 0.67 mL 1.33 mL
50 mM 0.03 mL 0.13 mL 0.27 mL

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产品说明书 for Bromocriptine mesylate

分析证书/产品说明书
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参考文献 for Bromocriptine mesylate

参考文献是支持产品生物活性的出版物。

Aubner et al (1990) Bromocriptine produces decreases in cocaine self-administration in the rat. Neuropsychopharmacology 3 101 PMID: 2317262

Lieberman and Goldstein (1985) Bromocriptine in Parkinson disease. Pharmacol.Rev. 37 217 PMID: 3901046

Seeman and Van Tol (1994) DA receptor pharmacology. TiPS 15 264 PMID: 7940991

Traub et al (1985) The effects of chronic bromocri. treatment on behaviour and DA receptor binding in the rat striatum. Eur.J.Pharmacol. 118 147 PMID: 3936723


If you know of a relevant reference for Bromocriptine mesylate, please let us know.

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关键词: Bromocriptine mesylate, Bromocriptine mesylate supplier, Selective, D2-like, agonists, Dopamine, Non-Selective, Receptors, D3, D4, dopaminergic, Non-selective, 0427, Tocris Bioscience

3 篇 Bromocriptine mesylate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Bromocriptine mesylate 的部分引用包括:

Pedersen et al (2021) A novel luminescence-based-β-arrestin recruitment assay for unmodified receptors. J Biol Chem 296 100503 PMID: 33684444

Liberante et al (2016) Identification and validation of the DA agonist bromocri. as a novel therapy for high-risk myelodysplastic syndromes and secondary acute myeloid leukemia. Oncotarget 7 6609 PMID: 26735888

Jia et al (2013) Age-dependent regulation of synaptic connections by DA D2 receptors. Nat Neurosci 16 1627 PMID: 24121738


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