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Bis-ANS is a fluorescent probe for nonpolar cavities in proteins. Used to detect Aβ fibre (Kd = ~80 nM); exhibits distinct fluorescent profiles for fibres and oligomers. Fluoresces in hydrophobic environments, negligible fluorescence in water solutions. Excitation\emission λ ~ 355\520 nm at pH 7.4. Also modulates liquid-liquid phase separation (LLPS) of TDP-43 low complexitry domain in vitro. Displays biphasic modulation; promotes LLPS at low concentrations but disprut liquid droplets at higher concentrations.
分子量 | 672.85 |
公式 | C32H22K2N2O6S2 |
储存 | Store at RT |
纯度 | ≥97% (HPLC) |
CAS Number | 65664-81-5 |
PubChem ID | 16213473 |
InChI Key | VWLWTJHKQHRTNC-UHFFFAOYSA-L |
Smiles | O=S(C1=CC=CC2=C1C(NC3=CC=CC=C3)=CC=C2C4=CC=C(NC5=CC=CC=C5)C6=C(S(=O)([O-])=O)C=CC=C46)([O-])=O.[K+].[K+] |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Rosen et al (1969) Dimer formation from 1-amino-8-naphthalenesulfonate catalyzed by bovine serum albumin. A new fluorescent molecule with exceptional binding properties. Biochemistry 8 3915 PMID: 5388144
Younan et al (2015) A comparison of three fluorophores for the detection of amyloid fibers and prefibrillar oligomeric assemblies. ThT (Thioflavin T); ANS (1-Anilinonaphthalene-8-sulfonic Acid); and bisANS (4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic Acid). Biochemistry 54 4297 PMID: 26087242
Babinchak et al (2020) Small molecules as potent biphasic modulators of protein liquid-liquid phase separation Nat.Commun. 11 5574 PMID: 33149109
关键词: Bis-ANS, Bis-ANS supplier, Amyloid, β, Aβ, peptides, fibers, fibres, oligomers, oligomeric, fluorescent, probe, detects, LLPS, liquid, phase, separation, Beta, Peptides, Fluorescent, B, Probes, 5908, Tocris Bioscience
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