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Cat.No. 5908 - Bis-ANS | C32H22K2N2O6S2 | CAS No. 65664-81-5
说明: Fluorescent probe for nonpolar cavities in proteins; used to detect Aβ fibres
化学名: 4,4'-Bis(phenylamino)-[1,1'-binaphthalene]-5,5'-disulfonic acid dipotassium salt
纯度: ≥97% (HPLC)
文献 (1)

生物活性 for Bis-ANS

Bis-ANS is a fluorescent probe for nonpolar cavities in proteins. Used to detect Aβ fibre (Kd = ~80 nM); exhibits distinct fluorescent profiles for fibres and oligomers. Fluoresces in hydrophobic environments, negligible fluorescence in water solutions. Excitation\emission λ ~ 355\520 nm at pH 7.4. Also modulates liquid-liquid phase separation (LLPS) of TDP-43 low complexitry domain in vitro. Displays biphasic modulation; promotes LLPS at low concentrations but disprut liquid droplets at higher concentrations.

技术数据 for Bis-ANS

分子量 672.85
公式 C32H22K2N2O6S2
储存 Store at RT
纯度 ≥97% (HPLC)
CAS Number 65664-81-5
PubChem ID 16213473
Smiles O=S(C1=CC=CC2=C1C(NC3=CC=CC=C3)=CC=C2C4=CC=C(NC5=CC=CC=C5)C6=C(S(=O)([O-])=O)C=CC=C46)([O-])=O.[K+].[K+]


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溶解性数据 for Bis-ANS

溶剂 最高浓度 mg/mL 最高浓度 mM
DMSO 67.28 100
water 13.46 20

制备储备液 for Bis-ANS

以下数据基于产品分子量 672.85。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.49 mL 7.43 mL 14.86 mL
5 mM 0.3 mL 1.49 mL 2.97 mL
10 mM 0.15 mL 0.74 mL 1.49 mL
50 mM 0.03 mL 0.15 mL 0.3 mL

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关键词: Bis-ANS, Bis-ANS supplier, Amyloid, β, Aβ, peptides, fibers, fibres, oligomers, oligomeric, fluorescent, probe, detects, LLPS, liquid, phase, separation, Beta, Peptides, Fluorescent, B, Probes, 5908, Tocris Bioscience

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