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BAY 9835

Cat. No. 8826 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent ADAMTS7 and ADAMTS12 inhibitor
化学名： 5,6-Difluoro-N-[[(4S)-4-(1-methyl-1H-pyrazol-5-yl)-2,5-dioxo-4-imidazolidinyl]methyl]-4'-(trifluoromethyl)-[1,1'-biphenyl]-2-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BAY 9835

BAY 9835 is a potent ADAMTS7 and ADAMTS12 inhibitor (IC50 values are 6 nM and 30 nM, respectively). BAY 9835 is selective over other metalloproteases (ADAMTS4, ADAMTS5, ADAM8, ADAM10, ADAM17, MMP2, MMP12, MMP14, MMP15). BAY 9835 is the first orally bioavailable ADAMTS7 inhibitor.

许可信息

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 9835 probe summary on the SGC website.

技术数据 for BAY 9835

分子量 493.39
公式 C22H16F5N5O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 3032487-31-0
PubChem ID 170836223
InChI Key LPQXZOJIUVOCAL-NRFANRHFSA-N
Smiles O=C(C1=C(C2=CC=C(C=C2)C(F)(F)F)C(F)=C(C=C1)F)NC[C@@]3(C4=CC=NN4C)NC(NC3=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BAY 9835

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 49.34 100

制备储备液 for BAY 9835

以下数据基于产品分子量 493.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.03 mL 10.13 mL 20.27 mL
5 mM 0.41 mL 2.03 mL 4.05 mL
10 mM 0.2 mL 1.01 mL 2.03 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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参考文献 for BAY 9835

参考文献是支持产品生物活性的出版物。

Meibom et al (2024) BAY-9835: Discovery of the first orally bioavailable ADAMTS7 inhibitor. J.Med.Chem. 67 2907 PMID: 38348661

If you know of a relevant reference for BAY 9835, please let us know.

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关键词: BAY 9835, BAY 9835 supplier, BAY9835, BAY-9835, potent, selective, orally, bioavailable, ADAMTS7, ADAMTS12, metalloprotease, MMPs, atherogenesis, metalloproteinases, inhibits, inhibitors, adams, ADAMs, Matrix, Metalloprotease, 8826, Tocris Bioscience

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