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Cat.No. 6626 - AP C5 | C16H13N5 | CAS No. 2234272-10-5
说明: Potent and selective PKG2 inhibitor
化学名: 4-[4-(1H-Imidazol-1-yl)phenyl]-N-2-propyn-1-yl-2-pyrimidinamine
纯度: ≥98% (HPLC)
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文献 (4)

生物活性 for AP C5

AP C5 is a potent and selective protein kinase G type II (PKG2) inhibitor (pIC50 = 7.2). Displays >20-fold selectivity for PKG2 over PKG1 and PKA (pIC50 values are 4.6 and 4.8 for PKG1 and PKA, respectively). Blocks 8-pCPT-cGMP-dependent VASP phosphorylation in intestinal organoids. Also attenuates toxin-stimulated anion secretory responses in mouse intestinal tissue.

化合物库 for AP C5

AP C5 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for AP C5

分子量 275.31
公式 C16H13N5
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2234272-10-5
PubChem ID 137919866
Smiles C#CCNC1=NC(C2=CC=C(N3C=CN=C3)C=C2)=CC=N1


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溶解性数据 for AP C5

溶剂 最高浓度 mg/mL 最高浓度 mM
DMSO 27.53 100
1eq. HCl 27.53 100

制备储备液 for AP C5

以下数据基于产品分子量 275.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.63 mL 18.16 mL 36.32 mL
5 mM 0.73 mL 3.63 mL 7.26 mL
10 mM 0.36 mL 1.82 mL 3.63 mL
50 mM 0.07 mL 0.36 mL 0.73 mL

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参考文献 for AP C5


Bijvelds et al (2018) Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors. J.Biol.Chem. 293 8173 PMID: 29653944

If you know of a relevant reference for AP C5, please let us know.



查看全部 Protein Kinase G Inhibitors

关键词: AP C5, AP C5 supplier, APC5, protein, kinase, g, type, 2, II, inhibitors, inhibits, guanosine, 3,5-cyclic, monophosphate, dependent, Protein, Kinase, G, 6626, Tocris Bioscience

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Development of a model system to form purified alternative pathway (AP) C5 convertases.
By Anonymous on 12/24/2019
种属: Human

We developed a model system to form purified alternative pathway (AP) C5 convertases on C3b-coated beads and quantify C5 conversion via functional analysis of released C5a.

review image


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