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Angiopep-2-Cys

Cat. No. 8902 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Binds to LRP1 and facilitates receptor-mediated transcytosis of cargo across the BBB
纯度： ≥95% (HPLC)
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引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Angiopep-2-Cys

Angiopep-2-Cys is a synthetic peptide able to specifically interact with low-density lipoprotein receptor-related protein 1 (LRP1) receptors present on brain endothelial cells and neurons. Angiopep-2-Cys is a conjugate of Angiopep-2 (Cat. No. 8828) and Cystein, and can be used to functionalize LNPs via thiol-maleimide click chemistry to target LRP1 receptors present on blood-brain barrier (BBB). mRNA LNPs functionalized with Angiopep-2-Cys shows improved transfection efficiency in cultured brain endothelial and neuronal cells, and in vivo, after systemic administration in mice.

技术数据 for Angiopep-2-Cys

分子量 2404.64
公式 C107H154N30O32S
序列 TFFYGGSRGKRNNFKTEEYC
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 906480-09-9
PubChem ID 170836226
InChI Key NTEVJSCQHIRPSH-ZYRNEBAYSA-N
Smiles O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC3=CC=C(C=C3)O)C(NCC(NCC(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CS)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Angiopep-2-Cys

溶解性 Soluble to 1 mg/ml in water

产品说明书 for Angiopep-2-Cys

分析证书目前不在网上提供。
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化学品安全技术说明书

参考文献 for Angiopep-2-Cys

参考文献是支持产品生物活性的出版物。

Han et al (2025) Peptide-functionalized lipid nanoparticles for targeted systemic mRNA delivery to the brain. Nano Lett. 25 800 PMID: 39688915

If you know of a relevant reference for Angiopep-2-Cys, please let us know.

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关键词: Angiopep-2-Cys, Angiopep-2-Cys supplier, Angiopep2Cys, Angiopep-2Cys, Angiopep-2, Cys, LRP1, peptides, low-density, lipoprotein, receptor-related, protein1, lipid, nanoparticles, mRNA, brain, delivery, blood-brain, barrier, BBB, neurons, Lipid, Nanoparticles, LDL, Receptors, Endocytosis, 8902, Tocris Bioscience

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