Alexidine dihydrochloride

Name: Alexidine dihydrochloride
Brand: Tocris Bioscience
SKU: 3979

Cat. No. 3979 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3979 has been discontinued.

View all Protein Tyrosine Phosphatases products.

说明： Selective inhibitor of PTPMT1

化学名： N,N''-Bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide dihydrochloride

说明书

引用文献 (1)

生物活性技术数据说明书参考文献

生物活性 for Alexidine dihydrochloride

Alexidine dihydrochloride is a selective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (PTPMT1) (IC₅₀ = 1.08 μM in vitro). Stimulates increased insulin secretion by β-cells in rat pancreatic islets. Displays antitcancer properties in FaDu cells. Also preserves functional hematopoietic stem cells ex vivo.

化合物库 for Alexidine dihydrochloride

Alexidine dihydrochloride is also offered as part of the Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Alexidine dihydrochloride

分子量	581.71
公式	C₂₆H₅₆N₁₀.2HCl
储存	Desiccate at -20°C
CAS Number	1715-30-6
PubChem ID	102678
InChI Key	BRJJFBHTDVWTCJ-UHFFFAOYSA-N
Smiles	N=C(NC(NCC(CC)CCCC)=N)NCCCCCCNC(NC(NCC(CC)CCCC)=N)=N.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Alexidine dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Alexidine dihydrochloride

参考文献是支持产品生物活性的出版物。

Yip et al (2006) Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent. Mol.Cancer Ther. 5 2234 PMID: 16985057

Doughty-Shenton et al (2010) Pharmacological targeting of the mitochondrial phosphatase PTPMT1. J.Pharmacol.Exp.Ther. 333 584 PMID: 20167843

Liu et al (2015) Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism. Blood 125 1562 PMID: 25593337

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1 篇 Alexidine dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Alexidine dihydrochloride 的部分引用包括：

Niemi et al (2013) Downregulation of the mitochondrial phosphatase PTPMT1 is sufficient to promote cancer cell death. PLoS One 8 e53803 PMID: 23326511