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3-pyr-Cytisine

Cat. No. 4125 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4125 has been discontinued.

说明： High affinity, partial agonist of α4β2 receptors
化学名： (1R,5S)-1,2,3,4,5,6-Hexahydro-9-(3-pyridinyl)-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for 3-pyr-Cytisine

High affinity α4β2 partial agonist (Ki values are 0.91, 119 and 1100 nM for α4β2, α3β4 and α7 receptors respectively). Shows little activity at α3β4 and α7 receptors. Exhibits antidepressant-like effects in mouse models of antidepressant efficacy.

技术数据 for 3-pyr-Cytisine

分子量 267.33
公式 C16H17N3O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 948027-43-8
PubChem ID 16731778
InChI Key GOYASQWDLRLAPK-WCQYABFASA-N
Smiles O=C2N1C[C@@]([H])(C4)CNC[C@@]([H])4C1=CC=C2C3=CC=CN=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for 3-pyr-Cytisine

参考文献是支持产品生物活性的出版物。

Mineur et al (2009) Cytisine-based nicotinic partial agonists as novel antidepressant compounds. J.Pharmacol.Exp.Ther. 329 377 PMID: 19164465

Papke et al (2010) Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. J.Pharmacol.Exp.Ther. 333 501 PMID: 20100906

Papke et al (2011) Electrophysiological perspectives on the therapeutic use of nicotinic acetylcholine receptor partial agonists. J.Pharmacol.Exp.Ther. 337 1

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关键词: 3-pyr-Cytisine, 3-pyr-Cytisine supplier, nicotinics, nachr, alpha4beta2, a4b2, α4β2, partial, agonists, Nicotinic, (a4b2), Receptors, 4125, Tocris Bioscience

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