ZIP

Pricing Availability   Qty
Cat.No. 2549 - ZIP | Myr-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu | CAS No. 863987-12-6
说明: Cell-permeable inhibitor of atypical PKC isozyme PKMζ
别名: z-Pseudosubstrate inhibitory peptide
说明书
引用文献 (8)
评论
文献 (3)

生物活性 for ZIP

ZIP is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.

Control Peptide and Biotinylated Peptide also available.

技术数据 for ZIP

分子量 1928.4
公式 C90H154N30O17
序列 SIYRRGARRWRKL

(Modifications: Ser-1 = Myr-Ser)

储存 Desiccate at -20°C
CAS Number 863987-12-6
PubChem ID 16156119
InChI Key CRKARHQCXWSUMV-HOHDCHNJSA-N
Smiles [H]N([C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O)C(=O)CCCCCCCCCCCCC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ZIP

溶解性 Soluble to 1 mg/ml in water

产品说明书 for ZIP

分析证书/产品说明书
选择另一批次:

参考文献 for ZIP

参考文献是支持产品生物活性的出版物。

Serrano et al (2005) Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation. J.Neurosci. 25 1979 PMID: 15728837

Pastalkova et al (2006) Storage of spatial information by the maintenance mechanism of LTP. Science 313 1141 PMID: 16931766

Ling et al (2002) Protein kinase Mz is necessary and sufficient for LTP maintenance. Nature Neurosci. 5 295


If you know of a relevant reference for ZIP, please let us know.

按产品操作查看相关产品

查看全部 Protein Kinase C Inhibitors

关键词: ZIP, ZIP supplier, Cell-permeable, inhibitors, inhibits, atypical, PKC, isozyme, PKMzeta, Protein, Kinases, C, z-Pseudosubstrate, inhibitory, peptide, Kinase, 2549, Tocris Bioscience

8 篇 ZIP 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ZIP 的部分引用包括:

Lee et al (2013) Prkcz null mice show normal learning and memory. Nature 493 416 PMID: 23283171

Grosso et al (2015) The higher order auditory cortex is involved in the assignment of affective value to sensory stimuli. Nat Commun 6 8886 PMID: 26619940

Balaban et al Homolog of protein kinase Mζ maintains context aversive memory and underlying long-term facilitation in terrestrial snail Helix. Front Cell Neurosci 9 222 PMID: 26157359

Awasthi et al (2019) Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting. Science 363 PMID: 30545844


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