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说明： DNA methyltransferase and cytidine deaminase inhibitor
别名： NSC 309132
化学名： 1-β-D-Ribofuranosyl-2(1H)-pyrimidinone
纯度： ≥98% (HPLC)
生物活性 for Zebularine
Zebularine is an orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC50 = 120 μM) and re-activates silenced genes in T24 bladder carcinoma cells. Inhibits cytidine deaminase (Ki ~ 2 μM); induces differentiation of mesenchymal stem cells into cardiomyocytes.
技术数据 for Zebularine
| 分子量 | 228.2 |
| 公式 | C9H12N2O5 |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 3690-10-6 |
| PubChem ID | 100016 |
| InChI Key | RPQZTTQVRYEKCR-WCTZXXKLSA-N |
| Smiles | O[C@@H]1[C@@H](CO)O[C@@H](N2C(N=CC=C2)=O)[C@@H]1O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Zebularine
参考文献 for Zebularine
参考文献是支持产品生物活性的出版物。
Laliberte et al (1992) Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2'-deoxycytidine by human cytidine deaminase. Cancer Chemother.Pharmacol. 30 7 PMID: 1375134
Ben-Kasus et al (2005) Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells. Biochem.Pharmacol. 70 121 PMID: 15885659
Naeem et al (2012) DNA methylation inhibitors, 5-azacytidine and zebularine potentiate the trans-differentiation of rat bone marrow mesenchymal stem cells into cardiomyocytes. Cardiovasc.Ther. [Epub ahead of print]
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关键词: Zebularine, Zebularine supplier, DNA, methyltransferase, inhibitors, inhibits, Transferases, cytidine, deaminases, NSC309132, dnmt, cardiomyocyte, differentiation, mesenchymal, stem, cells, epigenetics, NSC, 309132, Methyltransferases, Deaminases, Cardiomyocyte, Stem, Cells, Mesenchymal, 2293, Tocris Bioscience
4 篇 Zebularine 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Zebularine 的部分引用包括：
Zou et al (2019) The DNA Methylation Inhibitor Zebularine Controls CD4+ T Cell Mediated Intraocular Inflammation. Front Immunol 10 1950 PMID: 31475011
Biergans et al (2012) DNA methylation mediates the discriminatory power of associative long-term memory in honeybees. PLoS One 7 e39349 PMID: 22724000
Trowbridge et al (2012) Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains. Gastroenterology 26 344 PMID: 22345515
Soltoff and Lannon (2013) Activation of ERK1/2 by store-operated calcium entry in rat parotid acinar cells. PLoS One 8 e72881 PMID: 24009711
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Epigenetics in Cancer Research Product Guide
This product guide reviews some of the main areas in cancer epigenetics research and lists around 120 products that can be used for the main epigenetic targets including:
- Histone Methylation
- Histone Acetylation
- DNA Methylation
- Ubiquitination
- Bromodomains
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.