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WR 1065 dihydrochloride

Cat. No. 3356 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3356 has been discontinued.

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说明： p53 activator. Also ROS scavenger
化学名： 2-[(3-Aminopropyl)amino]ethanethiol dihydrochloride
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生物活性 技术数据 说明书 参考文献

生物活性 for WR 1065 dihydrochloride

WR 1065 dihydrochloride is a cell-permeable reactive oxygen species scavenger that activates p53 through a JNK-dependent signaling pathway. Activates p21waf-1 and MDM2, represses transcription of Myc and thymidine kinase, and inhibits DNA topoisomerase IIα. Induces cell cycle arrest and exhibits cytoprotective activity towards normal cells but not cancer cells in vivo. Also exhibits broad spectrum antiviral activity in vitro.

技术数据 for WR 1065 dihydrochloride

分子量 207.16
公式 C5H14N2S.2HCl
储存 Desiccate at -20°C
CAS Number 14653-77-1
PubChem ID 146169
InChI Key XDRLRDHLCIFZIW-UHFFFAOYSA-N
Smiles NCCCNCCS.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for WR 1065 dihydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for WR 1065 dihydrochloride

参考文献是支持产品生物活性的出版物。

North et al (2000) The cytoprotective aminothiol WR1065 activates p21waf-1 and down regulates cell cycle progression through a p53-dependent pathway. Oncogene 19 1206 PMID: 10713709

Pluquet et al (2003) The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase. J.Biol.Chem. 278 11879 PMID: 12531896

Walker et al (2009) WR1065 mitigates AZT-ddl-induced mutagenesis and inhibits viral replication. Enviorn.Mol.Mutagen. 50 460

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关键词: WR 1065 dihydrochloride, WR 1065 dihydrochloride supplier, WR1065, dihydrochloride, p53, activators, ROS, scavenger, Apoptosis, Cell, Cycle, Transcription, Factors, reactive, oxygen, species, Non-selective, Antivirals, 3356, Tocris Bioscience

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Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

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Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for WR 1065 dihydrochloride

p53 Signaling Pathway

p53 Signaling Pathway

p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.