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Submit ReviewVUF 5681 dihydrobromide
Discontinued Product
2493 has been discontinued.
View all Histamine H<sub>3</sub> Receptors products.
说明： Potent H3 receptor silent antagonist
化学名： 4-[3-(1H-Imidazol-4-yl)propyl]piperidine dihydrobromide
纯度： ≥98% (HPLC)
生物活性 for VUF 5681 dihydrobromide
VUF 5681 dihydrobromide is a potent histamine H3 receptor silent antagonist (pKi = 8.35).
技术数据 for VUF 5681 dihydrobromide
| 分子量 | 355.11 |
| 公式 | C11H19N3.2HBr |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 639089-06-8 |
| PubChem ID | 53440140 |
| InChI Key | YFFVIGXPKWSZHW-UHFFFAOYSA-N |
| Smiles | Br.Br.C(CC1CCNCC1)CC1=CNC=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for VUF 5681 dihydrobromide
参考文献 for VUF 5681 dihydrobromide
参考文献是支持产品生物活性的出版物。
Kitbunnadaj et al (2004) Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H3 receptor agonist. J.Med.Chem. 47 2414 PMID: 15115383
Leurs et al (2005) The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat.Rev.Drug Discov. 4 107 PMID: 15665857
Moreno-Delgado et al (2006) Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway. Neuropharmacology 51 517 PMID: 16769092
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关键词: VUF 5681 dihydrobromide, VUF 5681 dihydrobromide supplier, Potent, H3, receptor, silent, antagonists, Receptors, Histamine, histaminergic, VUF5681, dihydrobromide, 2493, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.
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