Vatalanib succinate

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Cat.No. 5680 - Vatalanib succinate | C20H15ClN4.C4H6O4 | CAS No. 212142-18-2
说明: Potent VEGFR inhibitor; also aromatase inhibitor
别名: CGP 79787D, PTK787/ZK222584
化学名: N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine succinate
纯度: ≥99% (HPLC)
说明书
引用文献 (1)
评论
文献 (3)
通路 (1)

生物活性 for Vatalanib succinate

Vatalanib succinate is a potent VEGFR inhibitor (IC50 values are 37 and 77 nM for VEGFR-2 and -1, respectively). Inhibits proliferation, migration and survival of HUVECs in vitro and inhibits growth, vascularization and metastasis of tumors expressing VEGFR in mouse models. Also inhibits PDGFR-β, c-Kit and c-Fms. Potent aromatase inhibitor (IC50 = 50 nM). Orally available.

化合物库 for Vatalanib succinate

Vatalanib succinate is also offered as part of the Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Vatalanib succinate

分子量 464.9
公式 C20H15ClN4.C4H6O4
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 212142-18-2
PubChem ID 151193
InChI Key LLDWLPRYLVPDTG-UHFFFAOYSA-N
Smiles ClC(C=C1)=CC=C1NC2=NN=C(CC3=CC=NC=C3)C4=CC=CC=C42.OC(CCC(O)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Vatalanib succinate

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 46.49 100

制备储备液 for Vatalanib succinate

以下数据基于产品分子量 464.9。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.76 mL 21.51 mL
5 mM 0.43 mL 2.15 mL 4.3 mL
10 mM 0.22 mL 1.08 mL 2.15 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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产品说明书 for Vatalanib succinate

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关键词: Vatalanib succinate, Vatalanib succinate supplier, CGP79787D, PTK787, ZK222584, aromatase, inhibitors, inhibits, vascular, endothelial, growth, factor, receptors, tyrosine, kinases, cancer, anticancer, VEGFR, angiogenesis, metastasis, CGP, 79787D, PTK787/ZK222584, Cytochrome, P450, 5680, Tocris Bioscience

1 篇 Vatalanib succinate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Vatalanib succinate 的部分引用包括:

Rasmussen et al (2018) Fish Scales Dictate the Pattern of Adult Skin Innervation and Vascularization. Dev Cell 46 344 PMID: 30032992


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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意,Tocris 仅会向正规科研企业/机构地址发送文献。


Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
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Kinases Product Listing

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
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Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for Vatalanib succinate

VEGF Signaling Pathway

VEGF Signaling Pathway

VEGF signaling pathway is involved in embryonic vascular development (vasculogenesis) and in the formation of new blood vessel (angiogenesis). It also induces cell migration, proliferation and survival.