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TransMoDE 3 Biotin

Cat. No. 8829 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Biotinylated angiopep-2, induces internalization and degradation of streptavidin in brain cell lines
纯度： ≥95% (HPLC)
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引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TransMoDE 3 Biotin

TransMoDE 3 Biotin is a biotinylated peptide capable of inducing both the degradation of target protein via lysosomal proteolysis and their bidirectional transcytosis of streptavidin across the blood-brain barrier. TransMoDE 3 Biotin is derived from the peptide Angiopep-2 (Cat. No. 8828).

技术数据 for TransMoDE 3 Biotin

分子量 2611.88
公式 C118H167N31O35S
序列 TFFYGGSRGKRNNFKTEEY

(Modifications: Thr-1 = N-terminal Ac, Lys-10 = N(ε)-Ac-Lys, Lys-15 = N(ε)-Biotin-Lys
储存 Store at -20°C
纯度 ≥95% (HPLC)
InChI Key SDTCWCCIHKRCLZ-MKHRACNQSA-N
Smiles O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC3=CC=C(C=C3)O)C(NCC(NCC(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCNC(C)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CCCCNC(CCCC[C@@H]5SC[C@@](N6)([H])[C@]5([H])NC6=O)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC7=CC=C(C=C7)O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TransMoDE 3 Biotin

溶解性 Soluble to 1 mg/ml in water

产品说明书 for TransMoDE 3 Biotin

分析证书/产品说明书
化学品安全技术说明书

参考文献 for TransMoDE 3 Biotin

参考文献是支持产品生物活性的出版物。

Howell et al (2024) Bifunctional Molecules That Induce Both Targeted Degradation and Transcytosis of Extracellular Proteins in Brain Cells. J Am Chem Soc 146 16404 PMID: 38855935

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关键词: TransMoDE 3 Biotin, TransMoDE 3 Biotin supplier, TransMoDE, 3, Biotin, TransMoDE-3-Biotin, Biotinylated, angiopep-2, LRP1, transcytosis, lysosomal, degradation, BBB, brain, Endocytosis, LYTAC, Building, Blocks, 8829, Tocris Bioscience

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