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TBIA

Cat. No. 7788 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

7788 has been discontinued.

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说明： Bivalent SHAPE cross-linking reagent
别名： trans-bis-isatoic anhydride
化学名： 1,6-Dihydrobenzo[1,2-d:4,5-d']bis([1,3]oxazine)-2,4,7,9-tetraone
纯度： ≥95% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for TBIA

TBIA (trans-bis-isatoic anhydride) is a bifunctional SHAPE (selective 2'-hydroxyl acylation analyzed by primer extension) chemical cross-linking reagent. TBIA has two electrophilic isatoic anhydride moieties, both of which can react with the 2'-OH group in nucleotides adjacent to and distant from the primary RNA sequence. TBIA is used in SHAPE-JuMP (-juxtaposed merged pairs) a technique for exploring RNA tertiary structure proximity on large RNAs, and higher-order RNA-RNA interactions at nanometer resolution.

技术数据 for TBIA

分子量 248.15
公式 C10H4N2O6
储存 Store at -20°C
纯度 ≥95% (HPLC)
InChI Key VKISDEPBWGUMCP-UHFFFAOYSA-N
Smiles O=C1OC(C2=C(N1)C=C3C(NC(OC3=O)=O)=C2)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for TBIA

参考文献是支持产品生物活性的出版物。

Christy et al (2021) Direct mapping of higher-order RNA interactions by SHAPE-JuMP. Biochemistry 60 1971 PMID: 34121404

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关键词: TBIA, TBIA supplier, TBIA, trans-bis-isatoic, anhydride, SHAPE-JuMP, bivalent, cross-linker, RNA-RNA, interactions, RNA, tertiary, structure, selective, 2'-hydroxyl, acylation, analyzed, by, primer, extension, and, mutational, profiling, DNA,, Protein, Synthesis, Biochemicals, Molecular, Biology, 7788, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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