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Submit ReviewST 1936 oxalate
说明： Selective, high affinity 5-HT6 agonist
化学名： 5-Chloro-3-[2-(dimethylamino)ethyl]-2-methylindole oxalate
纯度： ≥98% (HPLC)
生物活性 for ST 1936 oxalate
ST 1936 oxalate is a high affinity, selective agonist of 5-HT6 receptors (Ki values are 13, 168, and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors respectively). Displays moderate affinity for human α2 adrenergic receptors (Ki = 300 nM). Shown to increase Ca2+ concentration and phosphorylation of Fyn kinase, and regulate the activation of ERK1/2 in cloned cells.
技术数据 for ST 1936 oxalate
| 分子量 | 326.78 |
| 公式 | C13H17ClN2.C2H2O4 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1782228-83-4 |
| PubChem ID | 90488934 |
| InChI Key | FHSPBPPTDFRVGQ-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(NC(C)=C2CCN(C)C)C2=C1.OC(C(O)=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ST 1936 oxalate
参考文献 for ST 1936 oxalate
参考文献是支持产品生物活性的出版物。
Riccioni et al (2011) ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned 5-HT6 receptors. Eur.J.Pharmacol. 661 8 PMID: 21549693
Valentini et al (2011) A microdialysis study of ST1936, a novel 5-HT6 receptor agonist. Neuropharmacology 60 602 PMID: 21185318
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关键词: ST 1936 oxalate, ST 1936 oxalate supplier, ST1936, oxalate, selective, high, affinity, 5-ht6, agonists, 5-HT6, Receptors, 4337, Tocris Bioscience
1 篇 ST 1936 oxalate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 ST 1936 oxalate 的部分引用包括：
Yun et al (2016) Peripheral serotonin-mediated system suppresses bone development and regeneration via serotonin 6 G-protein-coupled receptor. Scientific Reports 6 30985 PMID: 27581523
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