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Submit ReviewPyroxamide
说明： Histone deacetylase inhibitor
化学名： N-Hydroxy-N'-3-pyridinyloctanediamide
纯度： ≥98% (HPLC)
生物活性 for Pyroxamide
Pyroxamide is an inhibitor of histone deacetylase (HDAC); potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells.
技术数据 for Pyroxamide
| 分子量 | 265.31 |
| 公式 | C13H19N3O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 382180-17-8 |
| PubChem ID | 4996 |
| InChI Key | PTJGLFIIZFVFJV-UHFFFAOYSA-N |
| Smiles | O=C(CCCCCCC(NO)=O)NC1=CC=CN=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Pyroxamide
参考文献 for Pyroxamide
参考文献是支持产品生物活性的出版物。
Butler et al (2001) Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase. Clin.Cancer Res. 7 962 PMID: 11309347
Remiszewski et al (2002) Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J.Med.Chem. 45 755 PMID: 11831887
Bradner et al (2010) Chemical phylogenetics of histone deacetylases. Nat.Chem.Biol. 6 238 PMID: 20139990
Carrillo et al (2015) Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT). Bioorg.Med.Chem. 23 5151 PMID: 25637120
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关键词: Pyroxamide, Pyroxamide supplier, Pyroxamide, hdac, histone, deacetylase, inhibitors, inhibits, epigenetics, Class, I, HDACs, 4403, Tocris Bioscience
1 篇 Pyroxamide 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Pyroxamide 的部分引用包括：
Kim (2018) Suppression of TGFβ-mediated conversion of endothelial cells and fibroblasts into cancer associated (myo)fibroblasts via HDAC inhibition. Br J Cancer 118 1359 PMID: 29695769
Pyroxamide 的评论
平均评分: 5 (Based on 1 Review.)
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TGF beta high responder treated with 1.5 μM Pyroxamide (HDAC 1 inhibitor) for 48 h. Cell lysates were analysed by western blot..
By
Anonymous on 11/15/2019
分析类型： In Vitro
种属： Human
细胞系/组织： C3-TAg tumour cell
TGF beta high responder treated with 1.5 μM Pyroxamide (HDAC 1 inhibitor) for 48 h. Cell lysates were analysed by western blot.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
Epigenetics in Cancer Poster
This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.
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Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.