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Submit ReviewNS 6784 hydrochloride
Discontinued Product
6140 has been discontinued.
说明： α7 nAChR agonist
化学名： 4-(5-Phenyl-1,3,4-oxadiazol-2-yl)-1,4-diazabicyclo[3.2.2]nonane hydrochloride
纯度： ≥98% (HPLC)
生物活性 for NS 6784 hydrochloride
α7 nAChR agonist at human and rat receptors (EC50 of 0.72 and 0.88 μM respectively). Stimulates α7 nAChR induced ERK phosphorylation in vitro and enhances avoidance learning in mice. Also evokes Ca2+ transients in IMR-32 neuroblastoma cells, with similar potency to PNU 282987 (Cat.No. 2303).
技术数据 for NS 6784 hydrochloride
| 分子量 | 306.79 |
| 公式 | C15H18N4O.HCl |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| PubChem ID | 132470911 |
| InChI Key | SLZGVSXFCPFOOO-UHFFFAOYSA-N |
| Smiles | N12CCC(N(C3=NN=C(C4=CC=CC=C4)O3)CC2)CC1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for NS 6784 hydrochloride
参考文献 for NS 6784 hydrochloride
参考文献是支持产品生物活性的出版物。
Kouhen et al (2009) Pharmacology of α7 nicotinic acetylcholine receptor mediated extracellular signal-regulatedkinase signalling in PC12 cells. Br.J.Pharmacol. 156 638 PMID: 19226255
Briggs et al (2009) Role of channel activation in cognitive enhancement mediated by α7 nicotinic acetylcholine receptors. Br.J.Pharmacol. 158 1486 PMID: 19845675
Ween et al (2010) α3* and α7 nAChR-mediated Ca2+ transient generation in IMR-32 neuroblastoma cells. Neurochem.Int. 57 269 PMID: 20558224
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关键词: NS 6784 hydrochloride, NS 6784 hydrochloride supplier, NS6784, HCl, 677723-97-6, alpha, 7, nicotinic, acetylcholine, receptors, activators, activates, agonists, nAChRs, Nicotinic, (a7), Receptors, 6140, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
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