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说明： Cyclooxygenase-inhibiting nitric oxide donor
化学名： (αS)-6-Methoxy-α-methyl-2-naphthaleneacetic acid (5S)-5,6-bis(nitrooxy)hexyl ester
纯度： ≥98% (HPLC)
生物活性 for NCX 466
NCX 466 is a cyclooxygenase (COX)-inhibiting nitric oxide (NO) donor (CINOD). Inhibits COX-1 and COX-2 while releasing NO. Demonstrates higher efficacy than naproxen, its congener drug, in reducing levels of profibrotic cytokine transforming growth factor-β and oxidative stress in a mouse model of bleomycin-induced lung fibrosis. Orally available.
技术数据 for NCX 466
| 分子量 | 436.41 |
| 公式 | C20H24N2O9 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1262956-64-8 |
| PubChem ID | 49855334 |
| InChI Key | QTUSNUCZIUBIBF-LIRRHRJNSA-N |
| Smiles | O=C(OCCCC[C@H](O[N+]([O-])=O)CO[N+]([O-])=O)[C@@H](C)C2=CC1=CC=C(OC)C=C1C=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for NCX 466
参考文献 for NCX 466
参考文献是支持产品生物活性的出版物。
Pini et al (2012) Prevention of bleomycin-induced lung fibrosis in mice by a novel approach of parallel inhibition of cyclooxygenase and nitric-oxide donation using NCX 466, a prototype cyclooxygenase inhibitor and nitric-oxide donor. J.Pharmacol.Exp.Ther. 341 493 PMID: 22344408
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关键词: NCX 466, NCX 466 supplier, NCX466, Cyclooxygenases, COX, COX1, COX2, COX-1, COX-2, inhibitors, inhibits, nitric, oxide, NO, donor, CINOD, inflammation, anti-inflammatory, profibrotic, Donors, /, Precursors, Cyclooxygenase, 4537, Tocris Bioscience
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