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Submit ReviewMS 245 oxalate
说明： High affinity 5-HT6 antagonist
化学名： 5-Methoxy-N,N-dimethyl-1-(phenylsulfonyl)-1H-indole-3-ethanamine oxalate
纯度： ≥99% (HPLC)
生物活性 for MS 245 oxalate
MS 245 oxalate is a high affinity 5-HT6 antagonist (Ki = 2.1 nM). Potentiates the hypolocomotor actions of (-)-nicotine in mice.
技术数据 for MS 245 oxalate
| 分子量 | 448.49 |
| 公式 | C19H22N2O3S.C2H2O4 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 275363-58-1 |
| PubChem ID | 6918541 |
| InChI Key | BLSWAEGCRSFTJG-UHFFFAOYSA-N |
| Smiles | O=S(N2C1=CC=C(OC)C=C1C(CCN(C)C)=C2)(C3=CC=CC=C3)=O.OC(C(O)=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for MS 245 oxalate
参考文献 for MS 245 oxalate
参考文献是支持产品生物活性的出版物。
Glennon et al (2000) 2-substituted tryptamines: agents with selectivity for 5-HT6 serotonin receptors. J.Med.Chem. 43 1011 PMID: 10715164
Dukat et al (2008) Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies. J.Med.Chem. 51 603 PMID: 18201064
Nirogi et al (2010) Novel and potent 5-piperazinyl methyl-N1-aryl sulfonyl indole derivatives as 5-HT6 receptor ligands. ACS Med.Chem.Lett. 1 340
Young et al (2006) Effect of the 5-HT6 serotonin antagonist MS-245 on the actions of (-)nicotine. Pharmacol.Biochem.Behav. 85 170 PMID: 16950502
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关键词: MS 245 oxalate, MS 245 oxalate supplier, MS245, 5ht6, serotonin, serotonergic, antagonists, 5-HT6, Receptors, 4208, Tocris Bioscience
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