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MitoBoronic acid

Cat. No. 7949 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Ratiometric mass spectrometry mitochondrial hydrogen peroxide (H2O2) probe
化学名： [(3-Boronophenyl)methyl]triphenylphosphonium bromide
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for MitoBoronic acid

MitoBoronic acid (MitoB) is a ratiometric mass spectrometry mitochondrial hydrogen peroxide (H2O2) probe. MitoBoronic acid is taken up into cells and accumulates inside the mitochondrial matrix where it reacts to H2O2 to be converted in MitoP. Measurement of MitoB/MitoP ratio by liquid chromatography tandem mass spectrometry (LC-MS/MS) is an indicator of the mitochondrial matrix H2O2 concentration. This method can be used in vitro and in vivo.

技术数据 for MitoBoronic acid

分子量 477.14
公式 C25H23BBrO2P
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1247025-84-8
PubChem ID 91885451
InChI Key VDNRROALFUZCBO-UHFFFAOYSA-M
Smiles OB(C1=CC=CC(C[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)=C1)O.[Br-]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MitoBoronic acid

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 47.71 100
ethanol 23.86 50 温和加热

制备储备液 for MitoBoronic acid

以下数据基于产品分子量 477.14。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.1 mL 10.48 mL 20.96 mL
5 mM 0.42 mL 2.1 mL 4.19 mL
10 mM 0.21 mL 1.05 mL 2.1 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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产品说明书 for MitoBoronic acid

分析证书/产品说明书
化学品安全技术说明书

参考文献 for MitoBoronic acid

参考文献是支持产品生物活性的出版物。

Cochemé et al (2012) Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila. Nat.Protoc. 7 946 PMID: 22517261

Gruszczyk et al (2022) Mitochondrial metabolism and bioenergetic function in an anoxic isolated adult mouse cardiomyocyte model of in vivo cardiac ischemia-reperfusion injury. Redox.Biol. 54 102368 PMID: 35749842

Cochemé et al (2011) Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix. Cell Metab. 13 340 PMID: 21356523

If you know of a relevant reference for MitoBoronic acid, please let us know.

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关键词: MitoBoronic acid, MitoBoronic acid supplier, MitoB, MitoP, mass, spectrometry, probe, H2O2, MitoP/MitoB, in, vivo, LC-MS/MS, ratiometric, ROS, Donors, 7949, Tocris Bioscience

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