LU AA33810

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Cat.No. 3562 - LU AA33810 | C19H25N3O2S3 | CAS No. 304008-29-5
说明: Potent NPY Y5 receptor antagonist
化学名: N-[[trans-4-[(4,5-Dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]methanesulfonamide
纯度: ≥98% (HPLC)
文献 (4)

生物活性 for LU AA33810

LU AA33810 is a potent neuropeptide Y (NPY) Y5 receptor antagonist (Ki = 1.5 nM in vitro). Displays ≥ 3300-fold affinity for Y5 over Y1, Y2 and Y4 receptors. Also binds human 5-HT2B and 5-HT1A receptors (Ki values are 247 and 478 nM respectively). Exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity.

化合物库 for LU AA33810

LU AA33810 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for LU AA33810

分子量 423.62
公式 C19H25N3O2S3
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 304008-29-5
PubChem ID 22254068
Smiles O=S(NC[C@H](CC4)CC[C@@H]4NC1=NC(C2=CC=CC=C2SCC3)=C3S1)(C)=O


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溶解性数据 for LU AA33810

溶剂 最高浓度 mg/mL 最高浓度 mM
DMSO 42.36 100

制备储备液 for LU AA33810

以下数据基于产品分子量 423.62。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.36 mL 11.8 mL 23.61 mL
5 mM 0.47 mL 2.36 mL 4.72 mL
10 mM 0.24 mL 1.18 mL 2.36 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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产品说明书 for LU AA33810


参考文献 for LU AA33810


Walker et al (2009) The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects J.Pharmacol.Exp.Ther. 328 900 PMID: 19098165

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关键词: LU AA33810, LU AA33810 supplier, LUAA33810, potent, NPY, neuropeptide, Y, receptors, Y5, antagonists, neuropeptides, Receptors, 3562, Tocris Bioscience

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