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Liperfluo

Cat. No. 8868 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Fluorescent lipid peroxide probe for live cell imaging
化学名： 2-[4-(Diphenylphosphino)phenyl]-9-(3,6,9,12-tetraoxatridec-1-yl)anthra[2,1,9-def :6,5,10-d'e'f']diisoquinoline-1,3,8,10(2H,9H)-tetrone
纯度： ≥90% (HPLC)
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生物活性 Scientific Data 技术数据 说明书 参考文献

生物活性 for Liperfluo

Key information: Liperfluo is a fluorescent probe for the selective detection and imaging of lipid peroxides in living cells. Upon reaction with lipid peroxides, Liperfluo is oxidized and becomes fluorescent.

Used for: imaging lipid peroxides in living cells. Liperfluo can be used to monitor lipid peroxidation in ferroptosis research.

Application: fluorescent microscopy and flow cytometry.

Properties and Photophysical Data: Liperfluo has a high solubility in organic solvents. It displays minimal photo damage and auto-fluorescence and shows high selectivity to lipid peroxidases over ROS and other radical species. Excitation and emission maxima (λ) measured in ethanol are 524 nm and 535 nm, respectively; quantum yield (oxidized form) = 0.85.

Scientific Data

Confocal Microscopy Fluorescence images of lipid peroxidation in HeLa cells View Larger

Fluorescence images of lipid peroxidation in HeLa cells. HeLa cells were pre-incubated in serum-free medium containing 1 μM Liperfluo at 37 °C for 30 min. in a 5% CO2 incubator. The medium was replaced by medium containing serum and 500 μM t-BHP and incubated at 37 °C for 60 min. in a 5% CO2 incubator. The cells were observed under a confocal fluorescence microscope.

Optical Data for Liperfluo

Emission Color Green
λabs 524 nm
λem 535 nm
Quantum Yield (φ) 0.85
Cell Permeable Yes
Application fluorescent microscopy, flow cytometry

Plan Your Experiments

Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

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技术数据 for Liperfluo

分子量 840.87
公式 C51H41N2O8P
储存 Store at +4°C
纯度 ≥90% (HPLC)
CAS Number 1448846-35-2
PubChem ID 166642656
InChI Key MDGOURRQWXHVBZ-UHFFFAOYSA-N
Smiles O=C1C2=CC=C3C4=CC=C5C(N(CCOCCOCCOCCOC)C(C6=CC=C(C4=C56)C7=C3C2=C(C(N1C8=CC=C(P(C9=CC=CC=C9)C%10=CC=CC=C%10)C=C8)=O)C=C7)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Liperfluo

参考文献是支持产品生物活性的出版物。

Yamanaka et al (2012) A novel fluorescent probe with high sensitivity and selective detection of lipid hydroperoxides in cells. RSC Adv. 2 7894

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关键词: Liperfluo, Liperfluo supplier, Liperfluo, fluorescent, probe, imaging, live, living, cells, detection, lipid, hydroperoxides, selective, sensitive, soluble, fluorescence, flow, cytometry, microscopy, ferroptosis, Fluorescent, Lipid, Probes, and, Cell, Membrane, Stains, Live-cell, Imaging, 8868, Tocris Bioscience

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Fluorescent Dyes and Probes Research Product Guide

Fluorescent Dyes and Probes Research Product Guide

This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:

  • Fluorescent Dyes, including Janelia Fluor® Dyes
  • Fluorescent Probes for Advanced Microscopy and Live Cell Imaging
  • Fluorescent Probes to Support In Vivo, Deep Tissue, and Bioluminescence Imaging
  • Fluorescent Probes and Reagents for Organoids and 3D Cell Culture Imaging
  • Aptamer-based RNA Imaging Reagents
  • Fluorescent Probes for Imaging Bacteria
  • TSA VividTM Fluorophore Kits
  • TSA Reagents for Enhancing IHC, ICC & FISH Signals
  • Tissue Clearing Kits and Reagents