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Isoginkgetin

Cat. No. 6483 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6483 has been discontinued.

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说明： Pre-mRNA splicing inhibitor; cell permeable
化学名： 8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for Isoginkgetin

Isoginkgetin is a pre-mRNA splicing inhibitor (IC50 ~ 30 μM); inhibits major and minor spliceosomes. Suppresses transcriptional elongation. Blocks spliceosome-mediated splicing process at the pre-spliceosome/A complex stage. Does not inhibit CDK9. Inhibits tumor cell invasion. Active in vivo. Cell permeable

技术数据 for Isoginkgetin

分子量 566.51
公式 C32H22O10
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 548-19-6
PubChem ID 5318569
InChI Key HUOOMAOYXQFIDQ-UHFFFAOYSA-N
Smiles COC1=CC=C(C2=CC(C3=C(C=C(C(C4=CC(C5=CC(C6=C(C=C(C=C6O5)O)O)=O)=CC=C4OC)=C3O2)O)O)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Isoginkgetin

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Isoginkgetin

参考文献是支持产品生物活性的出版物。

O'Brien et al (2008) The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing. J.Biol.Chem. 283 33147 PMID: 18826947

Szewczak et al (2017) The right tool for the job. Cell 169 561 PMID: 28475886

Boswell et al (2017) Total RNA-seq to identify pharmacological effects on specific stages of mRNA synthesis. Nat.Chem.Biol. 13 501 PMID: 28263964

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关键词: Isoginkgetin, Isoginkgetin supplier, mRNA, splicing, inhibitors, inhibits, cell-permeable, spliceosomes, transcriptional, elongation, DNA,, RNA, and, Protein, Synthesis, 6483, Tocris Bioscience

1 篇 Isoginkgetin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Isoginkgetin 的部分引用包括：

Sharon A et al (2021) Alternative splicing is a developmental switch for hTERT expression. Mol Cell 81 2349-2360.e6 PMID: 33852895

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