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Deazaflavin, Haloalkane

Cat. No. 8987 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Photosensitizer for proximity labeling experiments, NHS reactive group
化学名： N-(2-(2-((6-Chlorohexyl)oxy)ethoxy)ethyl)-2-(10-methyl-2,4-dioxo-4,10-dihydropyrimido[4,5-b]quinolin-3(2H)-yl)acetamide
纯度： ≥95% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Deazaflavin, Haloalkane

Deazaflavin, Haloalkane is a deazaflavin-based organic photocatalyst covalently linked to a chloroalkane ligand via a short PEG linker. The conjugate enables site-specific tethering of the photocatalyst to proteins genetically fused to HaloTag® in live-cell systems.

Upon blue light illumination (~450 nm), the deazaflavin moiety transfers energy to nearby photoactivatable probes (e.g., diazirines, aryl azides), initiating localized covalent labeling of biomolecules in the immediate vicinity of the HaloTag® fusion protein. The process is dependent on light exposure, the presence of the reactive probe, and spatial proximity to the tethered photocatalyst.

Deazaflavin, Haloalkane is designed for use in photoproximity labeling experiments that aim to study protein interactions or spatial proteomics in live mammalian cells under mild illumination conditions without the use of metal-based photocatalysts.

HaloTag® is a trademark of Promega Corporation.

技术数据 for Deazaflavin, Haloalkane

分子量 490.99
公式 C24H31ClN4O5
储存 Store at -20°C
纯度 ≥95% (HPLC)
InChI Key CFRUFYBIYIESMB-UHFFFAOYSA-N
Smiles O=C1N(C(C2=CC3=CC=CC=C3N(C2=N1)C)=O)CC(NCCOCCOCCCCCCCl)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Deazaflavin, Haloalkane

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 4.91 10

制备储备液 for Deazaflavin, Haloalkane

以下数据基于产品分子量 490.99。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 20.37 mL 101.84 mL 203.67 mL
0.5 mM 4.07 mL 20.37 mL 40.73 mL
1 mM 2.04 mL 10.18 mL 20.37 mL
5 mM 0.41 mL 2.04 mL 4.07 mL

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产品说明书 for Deazaflavin, Haloalkane

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Deazaflavin, Haloalkane

参考文献是支持产品生物活性的出版物。

Crocker et al (2025) Energy-transfer photoproximity labelling in live cells using an organic cofactor. Nat.Chem. doi: 10.1038 PMID: 40962911

If you know of a relevant reference for Deazaflavin, Haloalkane, please let us know.

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关键词: Deazaflavin, Haloalkane, Deazaflavin, Haloalkane supplier, Deazaflavin-Haloalkane, bioorthogonal, conjugation, bindind, binds, Halotag, cell-permeable, live, cells, protein-protein, interactions, photoproximity, labeling, photocatalyst, haloalkane, dehalogenase, Biochemicals, and, Molecular, Biology, 8987, Tocris Bioscience

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