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DBCO PEG4 Biotin

Cat. No. 7480 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

7480 has been discontinued.

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说明： Biotinylation reagent for labeling azide-containing biomolecules via Cu(I)-free click chemistry
化学名： (3aS,4S,6aR)-N-[19-(11,12-Didehydrodibenz[b,f]azocin-5(6H)-yl)-15,19-dioxo-3,6,9,12-tetraoxa-16-azanonadec-1-yl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide
纯度： ≥95% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for DBCO PEG4 Biotin

DBCO-PEG4-Biotin is a biotinylation reagent for labeling azide-containing biomolecules via Cu(I)-free Strain-Promoted Alkyne-Azide Click Chemistry (SPAAC) reaction. The hydrophilic PEG4 linker reduces or eliminates aggregation and precipitation during the labeling process by increasing the hydrophilicity of the target molecule. The PEG linker in DBCO-PEG4-Biotin also enhances the accessibility of the biotin moiety, improving the detection efficiency of the biotinylated molecule via fluorescent or HRP-labeled streptavidin or its affinity purification via streptavidin agarose.

技术数据 for DBCO PEG4 Biotin

分子量 749.92
公式 C39H51N5O8S
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 1255942-07-4
PubChem ID 91757917
InChI Key LNHSQAOQVNHUGL-QRBHCBQLSA-N
Smiles C(CCCC(NCCOCCOCCOCCOCCC(NCCC(=O)N1C=2C(C#CC=3C(C1)=CC=CC3)=CC=CC2)=O)=O)[C@H]4[C@@]5([C@](CS4)(NC(=O)N5)[H])[H]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for DBCO PEG4 Biotin

分析证书/产品说明书
化学品安全技术说明书

参考文献 for DBCO PEG4 Biotin

参考文献是支持产品生物活性的出版物。

Agard et al (2006) A comparative study of bioorthogonal reactions with azides. ACS Chem.Biol. 1 644 PMID: 17175580

Bernardim et al (2020) Precise installation of diazo-tagged side-chains on proteins to enable in vitro and in-cell site-specific labeling. Bioconjug.Chem. 31 1604 PMID: 32375474

Darabedian et al (2020) O-Acetylated chemical reporters of glycosylation can display metabolism-dependent background labeling of proteins but are generally reliable tools for the identification of glycoproteins. Front.Chem. 8 318 PMID: 32411667

Sawant et al (2016) A versatile toolbox for posttranscriptional chemical labeling and imaging of RNA. Nucleic Acids Res. 44 e16 PMID: 26384420

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关键词: DBCO PEG4 Biotin, DBCO PEG4 Biotin supplier, Cu(I)-free, Strain-Promoted, Alkyne-Azide, Click, Chemistry, SPAAC, copper-free, biotinylation, labeling, labelling, HRP, horseradish, peroxidase, streptavidin, fluorescent, fluorescence, imaging, Biochemicals, and, Molecular, Biology, 7480, Tocris Bioscience

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