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Cat.No. 1437 - D609 | C11H15OS2K | CAS No. 83373-60-8
说明: Selective PC-PLC inhibitor
化学名: O-(Octahydro-4,7-methano-1H-inden-5-yl) carbonopotassium dithioate
纯度: ≥98% (HPLC)
引用文献 (5)
评论 (2)
文献 (3)

生物活性 for D609

D609 is a selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (Ki = 6.4 μM); antiviral and antitumor agent. Also inhibits sphingomyelin synthase. Suppresses LPS- and IFNγ-induced NO production (IC50 = 20 mg/ml) and blocks oxidative glutamate toxicity in nerve cells. Antioxidant in vivo.

技术数据 for D609

分子量 266.46
公式 C11H15OS2K
储存 Desiccate at -20°C
纯度 ≥98% (HPLC)
CAS Number 83373-60-8
PubChem ID 4234241
Smiles S=C(S[K])OC1CC2C3CCCC3C1C2


Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for D609

溶剂 最高浓度 mg/mL 最高浓度 mM
water 26.65 100

制备储备液 for D609

以下数据基于产品分子量 266.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.75 mL 18.76 mL 37.53 mL
5 mM 0.75 mL 3.75 mL 7.51 mL
10 mM 0.38 mL 1.88 mL 3.75 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

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产品说明书 for D609


参考文献 for D609


Amtmann (1996) The antiviral, antitumoural xanthate D609 is a competitive inhibitor of phosphatidylcholine-specific phospholipase C. Drugs Exp.Clin.Res. 22 287 PMID: 9034754

Tschiakowsky et al (1994) Induction of nitric oxide synthase activity in phagocytic cells inhibited by tricyclodecan-9-yl-xanthogenate (D609). Br.J.Pharmacol. 113 664 PMID: 7532078

Zhou et al (2001) D609 inhibits ionizing radiation-induced oxidative damage by acting as a potent antioxidant. J.Pharmacol.Exp.Ther. 298 103 PMID: 11408530

Adibhatla et al (2012) Tricyclodecan-9-yl-xanthogenate (D609) mechanism of actions: a mini-review of literature. Neurochem.Res. 37 671 PMID: 22101393

If you know of a relevant reference for D609, please let us know.


查看全部 Phospholipase Inhibitors

关键词: D609, D609 supplier, Selective, PC-PLC, inhibitors, inhibits, Phospholipases, C, Esterases, Phospholipase, Other, Synthases/Synthetases, Non-selective, Antivirals, 1437, Tocris Bioscience

D609 的评论

平均评分: 4 (基于 2 条评论。)

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great product.
By Anonymous on 03/26/2020
分析类型: In Vitro
种属: Rat
细胞系/组织: Hippocampal neuron

100 μM treat 45min

review image

D609 does not inhibit LPA-induced COX-2 expression.
By Anonymous on 12/13/2018
分析类型: In Vitro
种属: Human
细胞系/组织: Osteosarcoma

Human osteosarcoma cells were incubated with 20 μM D609 for 30 min prior to treatment with 10 μM LPA to estimate COX-2 expression using Western blot analysis. D609 was ineffective against LPA-induced COX-2 expression while other inhibitors showed inhibition.

review image


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