[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide

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Cat.No. 1365 - [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide | Gly-Pro-Ser-Gln-Pro-Thr-Tyr-Pro-Gly-Asp-Asn-Ala-Thr-Pro-Glu-Gln-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-Arg-Tyr-Ile-Asn-Met-Ala-Aib-Arg-Gln-Arg-Tyr-NH2 | CAS No. 313988-89-5
说明: Potent, selective NPY Y5 agonist
纯度: ≥95% (HPLC)
说明书
引用文献
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文献 (4)

生物活性

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide is a potent, selective peptide agonist for the neuropeptide Y Y5 receptor (IC50 values for inhibition of NPY binding to human Y5, Y1, Y2 and Y4 receptors are 0.24, 530, > 500, and 51 nM respectively, Ki at Y5 = 0.1 - 0.15 nM). Stimulates food intake in vivo.

技术数据

分子量 4207.67
公式 C183H281N57O54S2
序列 GPSQPTYPGDNATPEQMARYYSALRRYINMAXRQRY

(Modifications: X = Aib, Tyr-36 = C-terminal amide)

储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 313988-89-5
PubChem ID 90479787
InChI Key DXMCMRQWOIRILO-VRGOUOKESA-N
Smiles [H]NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)NC(C)(C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据

溶解性 Soluble to 1 mg/ml in water

产品说明书

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参考文献

参考文献是支持产品生物活性的出版物。

Cabrele et al (2000) The first selective agonist for the neuropeptide YY5 receptor increases food intake in rats. J.Biol.Chem. 275 36043 PMID: 10944518

Dumont et al (2005) BODIPY®-conjugated neuropeptide Y ligands: new fluorescent tools to tag Y1, Y2, Y4 and Y5 receptor subtypes. Br.J.Pharmacol. 146 1069 PMID: 16231000


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关键词: [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide, [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide supplier, Potent, selective, neuropeptide, Y, Y5, agonists, Neuropeptide, Receptors, neuropeptides, NPY, 1365, Tocris Bioscience

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