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Submit ReviewCandesartan
Discontinued Product
4791 has been discontinued.
View all Angiotensin AT<sub>1</sub> Receptors products.
说明： AT1 antagonist
别名： CV 11974
化学名： 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid
纯度： ≥98% (HPLC)
生物活性 for Candesartan
Candesartan is an angiotensin II receptor 1 (AT1) antagonist (IC50 values are 1.12 and 2.86 nM in bovine adrenal cortex and rabbit aorta, respectively). Exhibits antihypertensive effects in animal models. Also available as a prodrug, candesartan cilexetil (Cat. No. 4792).
化合物库 for Candesartan
Candesartan is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Candesartan
| 分子量 | 440.45 |
| 公式 | C24H20N6O3 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 139481-59-7 |
| PubChem ID | 2541 |
| InChI Key | HTQMVQVXFRQIKW-UHFFFAOYSA-N |
| Smiles | CCOC1=NC(C=CC=C5C(O)=O)=C5N1CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Candesartan
参考文献 for Candesartan
参考文献是支持产品生物活性的出版物。
Shibouta et al (1993) Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (±)-1-(cyclohexyloxycarbonylox J.Pharmacol.Exp.Ther. 266 114 PMID: 8331552
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关键词: Candesartan, Candesartan supplier, Angiotensin, II, receptors, AT1, antagonists, CV11974, CV, 11974, Receptors, 4791, Tocris Bioscience
4 篇 Candesartan 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Candesartan 的部分引用包括：
Gemma et al (2021) Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19. Clin Sci (Lond) 135 465-481 PMID: 33479758
Milan et al (2021) Transcriptomic Analysis of Mouse Brain After Traumatic Brain Injury Reveals That the Angiotensin Receptor Blocker Candesartan Acts Through Novel Pathways. Front Neurosci 15 636259 PMID: 33828448
Ana et al (2022) Angiotensin Type-1 Receptor Inhibition Reduces NLRP3 Inflammasome Upregulation Induced by Aging and Neurodegeneration in the Substantia Nigra of Male Rodents and Primary Mesencephalic Cultures. Antioxidants (Basel) 11 PMID: 35204211
Rita et al (2022) Angiotensin type-1 receptor and ACE2 autoantibodies in Parkinson´s disease. NPJ Parkinsons Dis 8 76 PMID: 35701430
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