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Submit ReviewBVT 948
说明： Non-competitive protein tyrosine phosphatase inhibitor
化学名： 4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione
纯度： ≥98% (HPLC)
生物活性 for BVT 948
BVT 948 is a non-competitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC50 = 0.09 - 1.7 μM); displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. Enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo. Also inhibits several cytochrome P450 isoforms (IC50 <10 μM).
化合物库 for BVT 948
BVT 948 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。
技术数据 for BVT 948
| 分子量 | 241.25 |
| 公式 | C14H11NO3 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 39674-97-0 |
| PubChem ID | 6604934 |
| InChI Key | LLPBUXODFQZPFH-UHFFFAOYSA-N |
| Smiles | CC1(C)C(=O)N=C2C1=C(O)C(=O)C1=CC=CC=C21 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for BVT 948
参考文献 for BVT 948
参考文献是支持产品生物活性的出版物。
Liljebris et al (2004) Oxidation of protein tyrosine phosphatases as a pharmaceutical mechanism of action: a study using 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione. J.Pharmacol.Exp.Ther. 309 711 PMID: 14747616
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关键词: BVT 948, BVT 948 supplier, Non-competitive, protein, tyrosine, phosphatase, inhibitors, inhibits, enhances, insulin, signaling, PTP, Shp1, Shp2, Protein, Tyrosine, Phosphatases, BVT948, 2176, Tocris Bioscience
2 篇 BVT 948 的引用文献
引用文献是使用了 Tocris 产品的出版物。 BVT 948 的部分引用包括：
Hwang et al (2013) Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9. Am J Physiol Cell Physiol 46 533 PMID: 24152909
Chen et al (2014) BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals. Eur J Neurosci 39 1439 PMID: 24611998
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