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Bleomycin sulfate

Cat. No. 7147 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： DNA synthesis inhibitor. Induces pulmonary inflammation and fibrosis
别名： NSC125066
纯度： ≥90% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Bleomycin sulfate

Bleomycin sulfate is a glycopeptide antibiotic produced by Streptomyces verticillus. It inhibits DNA synthesis and causes single and double-strand breaks at specific base sequences in intracellular DNA of bacterial and mammalian cells. It also acts as an inducer and regulator of apoptosis and inhibits tumor angiogenesis. It is an anticancer agent for squamous cell carcinomas (SCC) with IC50 = 4 nM in UT-SCC-19A cells.

In vivo, Bleomycin sulfate induces pulmonary inflammation and fibrosis in lung injury models (mice).

Bleomycin sulfate contains two main components:

1) Bleomycin A2 hemisulfate, C55H84N17O21S3.HSO4, molecular weight = 1512.62 Da

2) Bleomycin B2, C55H84N20O21S2, molecular weight = 1425.52 Da.

The exact proportions vary from batch to batch and can be found on the relevant certificate of analysis.

技术数据 for Bleomycin sulfate

分子量 1512.6
公式 C55H84N17O21S3.HSO4 (for A2)
储存 Store at -20°C
纯度 ≥90% (HPLC)
CAS Number 9041-93-4
PubChem ID 9812642
InChI Key WUIABRMSWOKTOF-OYALTWQYSA-N
Smiles O=S(O)([O-])=O.O=C(N[C@@H]([C@@H](O[C@H]1[C@@H](O[C@@H]2[C@@H](O)[C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O2)[C@@H](O)[C@H](O)[C@H](CO)O1)C3=CN=CN3)C(N[C@@H]([C@H]([C@@H](C(N[C@H](C(NCCC4=NC(C5=NC(C(NCCC[S+](C)C)=O)=CS5)=CS4)=O)[C@@H](C)O)=O)C)O)C)=O)C6=NC([C@@H](NC[C@@H](C(N)=O)N)CC(N)=O)=NC(N)=C6C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Bleomycin sulfate

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 20 14
water 20 14

制备储备液 for Bleomycin sulfate

以下数据基于产品分子量 1512.6。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.14 mM 4.72 mL 23.61 mL 47.22 mL
0.7 mM 0.94 mL 4.72 mL 9.44 mL
1.4 mM 0.47 mL 2.36 mL 4.72 mL
7 mM 0.09 mL 0.47 mL 0.94 mL

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产品说明书 for Bleomycin sulfate

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Bleomycin sulfate

参考文献是支持产品生物活性的出版物。

D'Andrea et al (1978) Sequence specific cleavage of DNA by the antitumor antibiotics neocarzinostatin and bleomycin. Proc.Natl.Acad.Sci.USA 75 3608 PMID: 80799

Liu et al (2018) Telomere shortening activates TGF-β/Smads signaling in lungs and enhances both lipopolysaccharide and bleomycin-induced pulmonary fibrosis. Pharmacol.Sin 39 1735 PMID: 29925920

Lin et al (2015) Expression of human carcinoembryonic antigen-related cell adhesion molecule 6 and alveolar progenitor cells in normal and injured lungs of transgenic mice. Physiol.Rep 3 PMID: 26702074

Jääskelä-Saari et al (1997) Squamous cell cancer cell lines: sensitivity to bleomycin and suitability for animal xenograft studies. Acta Oto-Laryngologica 117 241 PMID: 9288321

Banerjee et al (2012) Characterization of lung stem cell niches in a mouse model of bleomycin-induced fibrosis. Stem Cell Res.Ther. 3 PMID: 22643035

If you know of a relevant reference for Bleomycin sulfate, please let us know.

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关键词: Bleomycin sulfate, Bleomycin sulfate supplier, Bleomycin, sulfate, NSC125066, DNA, synthesis, inhibitor, glycopeptide, antibiotic, breaks, single, double, strand, pulmonary, lung, fibrosis, injury, inflammation, models, induces, apoptosis, inhibits, angiogenesis, anticancer, antitumor, in, vivo, DNA,, RNA, and, Protein, Synthesis, Antibiotics, Apoptosis, Inducers, Antiangiogenics, 7147, Tocris Bioscience

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