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BF 738735

Cat. No. 6246 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6246 has been discontinued.

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说明： Potent and selective PI 4-kinase IIIβ inhibitor; broad spectrum enterovirus replication inhibitor
化学名： 2-Fluoro-4-[2-methyl-8-[[[3-(methylsulfonyl)phenyl]methyl]amino]imidazo[1,2-a]pyrazin-3-yl]phenol
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for BF 738735

BF 738735 is a potent and selective ATP-competitive phosphatidylinositol 4-kinase III beta (PI 4-KIIIβ) inhibitor (IC50 = 5.7 nM). Displays approximately 200-fold selectivity over PI 4-KIIIα. Broad spectrum enterovirus replication inhibitor.

技术数据 for BF 738735

分子量 426.47
公式 C21H19FN4O3S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1436383-95-7
PubChem ID 135742054
InChI Key IMHZCCZYPHJVMS-UHFFFAOYSA-N
Smiles CC1=C(C2=CC(F)=C(C=C2)O)N3C=CN=C(C3=N1)NCC4=CC(S(C)(=O)=O)=CC=C4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for BF 738735

参考文献是支持产品生物活性的出版物。

MacLeod et al (2013) Identification of a series of compounds with potent antiviral activity for the treatment of enterovirus infections. ACS Med.Chem.Lett. 4 585 PMID: 24900715

van der Schaar et al (2013) A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase III. Antimicrob.Agents Chemother. 57 4971

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关键词: BF 738735, BF 738735 supplier, BF738735, antiviral, inhibits, inhibitors, enteroviral, enterovirus, replication, Phosphatidylinositol, 4-kinase, beta, PI4K3b, PI4KIIIb, PI4K3beta, PI4KIIIbeta, Other, Kinases, Antivirals, 6246, Tocris Bioscience

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