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Submit ReviewBay 11-7821
Discontinued Product
1744 has been discontinued.
View all Ubiquitin/Ubl E2 Conjugating Enzymes products.
说明： E2 ubiquitin (Ub) conjugating enzymes inhibitor
别名： Bay 11-7082
化学名： (2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
纯度： ≥98% (HPLC)
生物活性 for Bay 11-7821
Bay 11-7821 is an E2 ubiquitin (Ub) conjugating enzyme inhibitor. Inhibits the conjugation of Ub to a range of E2 enzymes. Inhibits E2 enzyme mediated IκBα phosphorylation and indirectly decreases NF-κb activity. Also reversibly activates MAPK signaling. Induces apoptosis of leukemic T cell and B-cell lymphoma cell lines. Also inhibits activation of NLRP3 inflammasome. Binds and inhibits gasdermin D (GSDMD) pore formation. Pyroptosis inhibitor.
技术数据 for Bay 11-7821
| 分子量 | 207.25 |
| 公式 | C10H9NO2S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 19542-67-7 |
| PubChem ID | 5353431 |
| InChI Key | DOEWDSDBFRHVAP-KRXBUXKQSA-N |
| Smiles | CC1=CC=C(C=C1)S(=O)(=O)\C=C\C#N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Bay 11-7821
参考文献 for Bay 11-7821
参考文献是支持产品生物活性的出版物。
Mori et al (2002) Bay 11-7082 inhibits transcription factor NF-κB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells. Blood 100 1828 PMID: 12176906
Pierce et al (1997) Novel inhibitors of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J.Biol.Chem. 272 21096 PMID: 9261113
Strickson et al (2013) The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system. Biochem.J. 451 427 PMID: 23441730
Juliana et al (2010) Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome. J.Biol.Chem. 285 9792 PMID: 20093358
Pandeya et al (2019) Gasdermin D (GSDMD) as a new target for the treatment of infection. Medchemcomm 10 660 PMID: 31191857
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8 篇 Bay 11-7821 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Bay 11-7821 的部分引用包括：
Zhou (2017) TNFα induces tolerant production of CXC chemokines in colorectal cancer HCT116 cells via A20 inhibition of ERK signaling. Int Immunopharmacol 54 296 PMID: 29175508
Jiang (2017) Targeting the NLRP3 inflammasome to attenuate spinal cord injury in mice. J Neuroinflammation 14 207 PMID: 29070054
Ahn et al (2019) Nonsaponin fraction of Korean Red Ginseng attenuates cytokine production via inhibition of TLR4 expression. J Ginseng Res 43 291 PMID: 30976167
Clement et al (2014) CD31 is a key coinhibitory receptor in the development of immunogenic dendritic cells. Proc Natl Acad Sci U S A 111 E1101 PMID: 24616502
Han et al (2017) Nonsaponin fractions of Korean Red Ginseng extracts prime activation of NLRP3 inflammasome. J Ginseng Res 41 513 PMID: 29021698
Yu et al (2014) Differential effects of the Toll-like receptor 2 agonists, PGN and Pam3CSK4 on anti-IgE induced human mast cell activation. PLoS One 9 e112989 PMID: 25398056
Jia et al (2015) β-Catenin and NF-κB co-activation triggered by TLR3 stimulation facilitates stem cell-like phenotypes in breast cancer. Cell Death Differ 22 298 PMID: 25257174
Yang et al (2011) Constitutive NF-kappaB activation confers interleukin 6 (IL6) independence and resistance to dexameth. and Janus kinase inhibitor INCB018424 in murine plasmacytoma cells. J Biol Chem 286 27988 PMID: 21705340
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