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Submit ReviewAngiopep-2
说明： Binds to LRP1 and facilitates receptor-mediated transcytosis of cargo across the BBB
纯度： ≥95% (HPLC)
生物活性 for Angiopep-2
Angiopep-2 is a synthetic peptide able to specifically interact with low-density lipoprotein receptor-related protein 1 (LRP1) receptors present both on blood-brain barrier (BBB) and tumor cell membranes. Angiopep-2 binding to LRP1 facilitates receptor-mediated transcytosis of cargo across the BBB. Transcytosis-inducing molecular degraders of extracellular proteins (TransMoDEs), containing Angiopep-2 and modified to include a small-molecule ligand, induce target internalization that can cross the BBB in a variety of cell types.
技术数据 for Angiopep-2
| 分子量 | 2301.5 |
| 公式 | C104H149N29O31 |
| 序列 | TFFYGGSRGKRNNFKTEEY |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| PubChem ID | 134687501 |
| InChI Key | RCVVJXYDPKEONQ-JVFWYHQTSA-N |
| Smiles | O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC3=CC=C(C=C3)O)C(NCC(NCC(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC5=CC=C(C=C5)O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Angiopep-2
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for Angiopep-2
参考文献 for Angiopep-2
参考文献是支持产品生物活性的出版物。
Howell et al (2024) Bifunctional molecules that induce both targeted degradation and transcytosis of extracellular proteins in brain cells. J.Am.Chem.Soc. 146 16404 PMID: 38855935
Costagliola di Polidoro et al (2022) Revealing angiopep-2/LRP1 molecular interaction for optimal delivery to glioblastoma (GBM). Molecules 27 6696 PMID: 36235232
If you know of a relevant reference for Angiopep-2, please let us know.
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关键词: Angiopep-2, Angiopep-2 supplier, Angiopep2, Angiopep, 2, blood-brain, barrier, BBB, LRP1, peptides, low-density, lipoprotein, receptor-related, protein1, endocytosis, TPD, targeted, protein, degradation, LDL, Receptors, LYTAC, Building, Blocks, 8828, Tocris Bioscience
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