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说明： DNA polymerase λ and β inhibitor
化学名： (5Z)-5-[[(4-[(2-Methylphenyl)thio]-3-nitrophenyl]methylene]-2-thioxo-4-thiazolidinone
纯度： ≥98% (HPLC)
生物活性 for AM-TS23
DNA polymerase λ and β inhibitor (IC50 values are 3.9 and 18.2 μM, respectively). Sensitizes human colorectal cancer cells to hydrogen peroxide and temozolomide (Cat. No. 2706) in vitro.
技术数据 for AM-TS23
| 分子量 | 388.48 |
| 公式 | C17H12N2O3S3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1489285-17-7 |
| PubChem ID | 72164414 |
| InChI Key | SHKDXDWJERWCHI-DHDCSXOGSA-N |
| Smiles | O=C(/C(S2)=C/C1=CC=C(SC3=CC=CC=C3C)C([N+]([O-])=O)=C1)NC2=S |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AM-TS23
参考文献 for AM-TS23
参考文献是支持产品生物活性的出版物。
Strittmatter et al (2014) Expanding the scope of human DNA polymerase λ and β inhibitors. ACS Chem.Biol. 9 282 PMID: 24171552
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关键词: AM-TS23, AM-TS23 supplier, DNA, polymerases, inhibitors, lambda, beta, cancer, sensitizers, AM-TS23, β, λ, inhibits, Polymerase, DNA,, RNA, and, Protein, Synthesis, 5211, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.