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Submit ReviewA 939572
Discontinued Product
4845 has been discontinued.
说明： Potent SCD-1 inhibitor
化学名： 4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-piperidinecarboxamide
纯度： ≥99% (HPLC)
生物活性 for A 939572
A 939572 is a potent stearoyl-CoA desaturase 1 (SCD1) inhibitor (IC50 = 0.4 nM). Selective for SCD1 over a range of kinases and hERG channels. Inhibits proliferation of squamous cell carcinoma FaDu cells in vitro. Also induces cell death of undifferentiated human embryonic stem cells (ESCs). Orally bioavailable.
化合物库 for A 939572
A 939572 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for A 939572
| 分子量 | 387.86 |
| 公式 | C20H22ClN3O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1032229-33-6 |
| PubChem ID | 24905400 |
| InChI Key | DPYTYQFYDLYWHZ-UHFFFAOYSA-N |
| Smiles | O=C(NC3=CC(C(NC)=O)=CC=C3)N1CCC(OC2=C(Cl)C=CC=C2)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for A 939572
参考文献 for A 939572
参考文献是支持产品生物活性的出版物。
Ben-David et al (2013) Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. Cell Stem Cell 12 167 PMID: 23318055
Xin et al (2008) Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors. Bioorg.Med.Chem.Lett. 18 4298 PMID: 18632269
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关键词: A 939572, A 939572 supplier, A939572, potent, stearoyl-co1, desaturase, inhibitors, inhibits, SCD1, stem, cells, lipid, metabolism, Stearoyl-CoA, 9-desaturase, ESCs, and, iPSC, 4845, Tocris Bioscience
1 篇 A 939572 的引用文献
引用文献是使用了 Tocris 产品的出版物。 A 939572 的部分引用包括：
Lien et al (2021) Low glycaemic diets alter lipid metabolism to influence tumour growth Nature 599 302 PMID: 34671163
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