A 331440 dihydrochloride


A 331440 dihydrochloride(目录编号 @cat_num)因商业原因已下架.
Cat.No. 4697 - A 331440 dihydrochloride | CAS No. 1049740-32-0
说明: Selective H3 antagonist
化学名: 4'-[3-[(3R)-3-(Dimethylamino)-1-pyrrolidinyl]propoxy]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride
纯度: ≥98% (HPLC)
文献 (4)

生物活性 for A 331440 dihydrochloride

A 331440 dihydrochloride is a high affinity histamine H3 receptor antagonist (Ki values are 21.7 and 22.7 nM for rat and human H3 receptors, respectively). Exhibits selectivity for human H3 over H1, H2 and H4 receptors (Ki values are 2940, 14400 and >10000 nM respectively). Shown to reduce weight in a diet-induced obesity model.

技术数据 for A 331440 dihydrochloride

分子量 422.39
公式 C22H27N3O.2HCl
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 1049740-32-0
PubChem ID 16078942
Smiles CN(C)[C@H](CC3)CN3CCCOC1=CC=C(C2=CC=C(C#N)C=C2)C=C1.Cl.Cl


Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for A 331440 dihydrochloride

参考文献 for A 331440 dihydrochloride


Hancock et al (2004) Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist. Eur.J.Pharmacol. 487 183 PMID: 15033391

Hancock et al (2004) In vitro optimization of structure activity relationships by analogues of A-331440 combining radioligand receptor binding assays and micronucleus assays of potential antiobesity histamine H3 receptor antagonists. Basic Clin.Pharmacol.Toxicol. 95 144 PMID: 15447739



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关键词: A 331440 dihydrochloride, A 331440 dihydrochloride supplier, A331440, dihydrochloride, high, affinity, selective, histamine, histaminergic, H3, receptor, antagonists, anti-obesity, obese, Histamine, Receptors, 4697, Tocris Bioscience

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