A 331440 dihydrochloride

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Cat.No. 4697 - A 331440 dihydrochloride | CAS No. 1049740-32-0
说明: Selective H3 antagonist
化学名: 4'-[3-[(3R)-3-(Dimethylamino)-1-pyrrolidinyl]propoxy]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride
纯度: ≥98% (HPLC)
说明书
引用文献
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文献 (4)

生物活性 for A 331440 dihydrochloride

A 331440 dihydrochloride is a high affinity histamine H3 receptor antagonist (Ki values are 21.7 and 22.7 nM for rat and human H3 receptors, respectively). Exhibits selectivity for human H3 over H1, H2 and H4 receptors (Ki values are 2940, 14400 and >10000 nM respectively). Shown to reduce weight in a diet-induced obesity model.

技术数据 for A 331440 dihydrochloride

分子量 422.39
公式 C22H27N3O.2HCl
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 1049740-32-0
PubChem ID 16078942
InChI Key XFPYVTSGYYMTFS-GHVWMZMZSA-N
Smiles CN(C)[C@H](CC3)CN3CCCOC1=CC=C(C2=CC=C(C#N)C=C2)C=C1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for A 331440 dihydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 42.24 100
DMSO 8.45 20

制备储备液 for A 331440 dihydrochloride

以下数据基于产品分子量 422.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.37 mL 11.84 mL 23.67 mL
5 mM 0.47 mL 2.37 mL 4.73 mL
10 mM 0.24 mL 1.18 mL 2.37 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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产品说明书 for A 331440 dihydrochloride

参考文献 for A 331440 dihydrochloride

参考文献是支持产品生物活性的出版物。

Hancock et al (2004) Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist. Eur.J.Pharmacol. 487 183 PMID: 15033391

Hancock et al (2004) In vitro optimization of structure activity relationships by analogues of A-331440 combining radioligand receptor binding assays and micronucleus assays of potential antiobesity histamine H3 receptor antagonists. Basic Clin.Pharmacol.Toxicol. 95 144 PMID: 15447739


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关键词: A 331440 dihydrochloride, A 331440 dihydrochloride supplier, A331440, dihydrochloride, high, affinity, selective, histamine, histaminergic, H3, receptor, antagonists, anti-obesity, obese, Histamine, Receptors, 4697, Tocris Bioscience

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