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A 331440 dihydrochloride
生物活性 for A 331440 dihydrochloride
A 331440 dihydrochloride is a high affinity histamine H3 receptor antagonist (Ki values are 21.7 and 22.7 nM for rat and human H3 receptors, respectively). Exhibits selectivity for human H3 over H1, H2 and H4 receptors (Ki values are 2940, 14400 and >10000 nM respectively). Shown to reduce weight in a diet-induced obesity model.
技术数据 for A 331440 dihydrochloride
|储存||Desiccate at RT|
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参考文献 for A 331440 dihydrochloride
Hancock et al (2004) Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist. Eur.J.Pharmacol. 487 183 PMID: 15033391
Hancock et al (2004) In vitro optimization of structure activity relationships by analogues of A-331440 combining radioligand receptor binding assays and micronucleus assays of potential antiobesity histamine H3 receptor antagonists. Basic Clin.Pharmacol.Toxicol. 95 144 PMID: 15447739
关键词: A 331440 dihydrochloride, A 331440 dihydrochloride supplier, A331440, dihydrochloride, high, affinity, selective, histamine, histaminergic, H3, receptor, antagonists, anti-obesity, obese, Histamine, Receptors, 4697, Tocris Bioscience
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Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.