A 317491 sodium salt

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Cat.No. 6493 - A 317491 sodium salt | C33H25NO8Na2
说明: Selective, high affinity P2X3 and P2X2/3 antagonist; antinociceptive
化学名: 5-[[[(3-Phenoxyphenyl)methyl][(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]carbonyl]-1,2,4-benzenetricarboxylic acid disodium salt
纯度: ≥98% (HPLC)
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生物活性 for A 317491 sodium salt

A 317491 sodium salt is a selective, high affinity non-nucleotide P2X3 and P2X2/3 receptor antagonist (Ki values are 9, 22, 22 and 92 nM at human P2X2/3, rat P2X3, human P2X3 and rat P2X2/3, respectively); blocks recombinant human and rat P2X3 and P2X2/3 receptor-mediated calcium flux (Ki = 22 - 92 nM). Exhibits selectivity over other P2 receptors and other neurotransmitter receptors, ion channels, and enzymes (IC50 > 5 μM). Reduces mechanical allodynia and thermal hyperalgesia in the CCI in vivo models. Antinociceptive.

技术数据 for A 317491 sodium salt

分子量 609.54
公式 C33H25NO8Na2
储存 Store at -20°C
纯度 ≥98% (HPLC)
Smiles O=C(C1=CC(C(O)=O)=C(C(N([C@H]2CCCC3=CC=CC=C23)CC4=CC(OC5=CC=CC=C5)=CC=C4)=O)C=C1C(O[Na])=O)O[Na]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for A 317491 sodium salt

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 60.95 100

制备储备液 for A 317491 sodium salt

以下数据基于产品分子量 609.54。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.64 mL 8.2 mL 16.41 mL
5 mM 0.33 mL 1.64 mL 3.28 mL
10 mM 0.16 mL 0.82 mL 1.64 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

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关键词: A 317491 sodium salt, A 317491 sodium salt supplier, A317491, selective, high, affinity, non-nucleotide, P2X3, P2X2/3, receptor, antagonists, antagonism, antinociceptive, mechanical, allodynia, hyperalgesia, active, in, vivo, P2X, Receptors, 6493, Tocris Bioscience

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