7-Aminoactinomycin D

Name: 7-Aminoactinomycin D
Brand: Tocris Bioscience
SKU: 7121

Cat. No. 7121 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

7121 has been discontinued.

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说明： Red-fluorescent DNA stain, membrane impermeant to live cells. Used for: apoptosis detection, cell viability staining. Application: flow cytometry, fluorescence microscopy

化学名： 2,7-Diamino-N¹,N⁹-bis(6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxohexadecahydro-1H-pyrrolo[2,1-i][1]oxa[4,7,10,13]tetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide

纯度： ≥97% (HPLC)

说明书

引用文献

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for 7-Aminoactinomycin D

Key information: 7-aminoactinomycin D (7-AAD) is a red-fluorescent DNA stain. It is membrane impermeant to live cells but penetrates dead or damaged cells.

Used for: cell cycle studies, selective detection of dead cells by flow cytometry, chromosome banding analysis, cell sorting, and apoptosis quantification.

Application: fluorescence microscopy and flow cytometry.

Properties and Photophysical Data: G-C base-specific DNA intercalator that forms stable complexes with DNA. May be used in combination with FITC (Cat. No. 5440) or phycoerythrin (PE). Fluorescent analogue of actinomycin D (Cat. No. 1229). Can be excited using 488 nm (blue), 532 nm (green), and 561 nm (yellow-green) laser lines. Suitable for multicolor fluorescence microscopy experiments. Excitation and emission maxima (λ) are 549 nm and 655 nm, respectively.

Optical Data for 7-Aminoactinomycin D

λ_abs	549 nm
λ_em	655 nm
Application	Fluorescence Microscopy, Flow Cytometry

Plan Your Experiments

Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

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技术数据 for 7-Aminoactinomycin D

分子量	1270.45
公式	C₆₂H₈₇N₁₃O₁₆
储存	Store at -20°C
纯度	≥97% (HPLC)
CAS Number	7240-37-1
PubChem ID	14924508
InChI Key	YXHLJMWYDTXDHS-UHFFFAOYSA-N
Smiles	NC1=C(C(NC(C(C)OC(C(C(C)C)N(C(CN(C)C2=O)=O)C)=O)C(NC(C(C)C)C(N3C2CCC3)=O)=O)=O)C4=NC5=C(C(NC(C(NC(C(C)C)C6=O)=O)C(C)OC(C(C(C)C)N(C(CN(C)C(C7N6CCC7)=O)=O)C)=O)=O)C=C(N)C(C)=C5OC4=C(C)C1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for 7-Aminoactinomycin D

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 7-Aminoactinomycin D

参考文献是支持产品生物活性的出版物。

Zelenin et al (1984) 7-Amino-actinomycin D as a specific fluorophore for DNA content analysis by laser flow cytometry. Cytometry 5 348 PMID: 6468175

Schmid et al (1992) Dead cell discrimination with 7-amino-actinomycin D in combination with dual color immunofluorescence in single laser flow cytometry. Cytometry 13 204 PMID: 1547670

Philpott et al (1996) The use of 7-amino actinomycin D in identifying apoptosis: Simplicity of use and broad spectrum of application compared with other techniques. Blood 87 2244 PMID: 8630384

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