Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Review3-Nitropropionic acid
说明： Irreversible mitochondrial respiratory complex II inhibitor
纯度： ≥97% (HPLC)
生物活性 for 3-Nitropropionic acid
3-Nitropropionic acid is an irreversible mitochondrial respiratory complex II (succinate dehydrogenase) inhibitor; induces autophagy in SH-SY5Y cells. Recapitulates Huntington's disease-like pathology and symptoms in primate and rodent models.
技术数据 for 3-Nitropropionic acid
| 分子量 | 119.08 |
| 公式 | C3H5NO4 |
| 储存 | Store at +4°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 504-88-1 |
| PubChem ID | 1678 |
| InChI Key | WBLZUCOIBUDNBV-UHFFFAOYSA-N |
| Smiles | OC(CC[N+]([O-])=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for 3-Nitropropionic acid
参考文献 for 3-Nitropropionic acid
参考文献是支持产品生物活性的出版物。
de Oca Balderas et al (2013) Mitochondrial impairment induced by 3-nitropropionic acid is enhanced by endogenous metalloprotease activity inhibition in cultured rat striatal neurons. Neurosci.Lett. PMID: 23643981
Solesio et al (2013) 3-Nitropropionic acid induces autophagy by forming mitochondrial permeability transition pores rather than activating the mitochondrial fission pathway. Br.J.Pharmacol. 168 63 PMID: 22509855
Huang et al (2005) 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. J.Biol.Chem. 28 5965 PMID: 16371358
按产品操作查看相关产品
关键词: 3-Nitropropionic acid, 3-Nitropropionic acid supplier, 3-Nitropropionic, acid, mitochondrial, complex, II, inhibitors, inhibits, oxidative, stress, Huntingtons, autophagy, succinate, dehydrogenase, 3-NP, Oxidative, Phosphorylation, Autophagy, Other, Dehydrogenases, 4849, Tocris Bioscience
3-Nitropropionic acid 的评论
目前没有该产品的评论。 Be the first to review 3-Nitropropionic acid and earn rewards!
Have you used 3-Nitropropionic acid?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cancer Metabolism Research Product Guide
This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:
- Glycolysis
- Tricarboxylic Acid Cycle
- Lipidogenesis
- 1C Metabolism and Nucleic Acid Synthesis
- Drivers of Metabolic Reprogramming
- pH and Redox Balance