ZNL 02-096

Pricing Availability   Qty
Cat.No. 7240 - ZNL 02-096 | C42H45N11O6 | CAS No. 2414418-49-6
说明: Potent and selective Wee1 Degrader (PROTAC®)
化学名: 4-((3-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)propyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
纯度: ≥98% (HPLC)
文献 (4)

生物活性 for ZNL 02-096

ZNL 02-096 is a potent and selective Wee1 Degrader (PROTAC®) that comprises the Wee1 inhibitor AZD 1775 joined by a linker to the cereblon-binding ligand Pomalidomide (Cat. No. 6302). ZNL 02-096 selectively degrades Wee1 at submicromolar concentrations, while sparing PLK1, an AZD 1775 secondary target. In MOLT-4 cells in vitro, ZNL 02-096 induces degradation of Wee1, accumulation of DNA damage, arrest of the cell cycle in the G2/M phase and apoptosis. The compound shows antiproliferative effects in a panel of 300 cancer cell lines.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.


Sold under license from Dana-Farber Cancer Institute.

技术数据 for ZNL 02-096

分子量 799.89
公式 C42H45N11O6
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2414418-49-6
PubChem ID 153555373
Smiles CC(O)(C1=NC(N2N(C(C3=CN=C(N=C23)NC4=CC=C(N5CCN(CC5)CCCNC6=C7C(N(C(C7=CC=C6)=O)C8CCC(NC8=O)=O)=O)C=C4)=O)CC=C)=CC=C1)C


Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ZNL 02-096

溶剂 最高浓度 mg/mL 最高浓度 mM
DMSO 39.99 50

制备储备液 for ZNL 02-096

以下数据基于产品分子量 799.89。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 2.5 mL 12.5 mL 25 mL
2.5 mM 0.5 mL 2.5 mL 5 mL
5 mM 0.25 mL 1.25 mL 2.5 mL
25 mM 0.05 mL 0.25 mL 0.5 mL

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参考文献 for ZNL 02-096


Li et al (2020) Development and characterization of a Wee1 kinase degrader. Cell Chem.Biol. 27 57 PMID: 31735695

If you know of a relevant reference for ZNL 02-096, please let us know.

关键词: ZNL 02-096, ZNL 02-096 supplier, ZNL02-096, Wee1, Degrader, PROTAC, PROTACs, AZD, 1775, selective, TPD, targeted, protein, degradation, Active, Degraders, Checkpoint, Kinases, Control, 7240, Tocris Bioscience

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