VH 032 amide-PEG2-alkyne

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Cat.No. 6684 - VH 032 amide-PEG2-alkyne | C31H42N4O7S | CAS No. 2098799-80-3
说明: VHL ligand with PEG linker and terminal alkyne for onward chemistry
别名: VH 032 - linker 6
化学名: (2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-6,9,12-trioxa-3-azapentadec-14-yn-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
纯度: ≥95% (HPLC)
文献 (1)

生物活性 for VH 032 amide-PEG2-alkyne

VH 032 amide-PEG2-alkyne is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC® research and development; incorporates an E3 ligase ligand plus PEG2 linker with terminal alkyne ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

This product has been recently renamed. The previous name for this product was VH 032 - linker 6

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines for VH 032 amide-PEG2-alkyne

This product is provided for use in onward chemistry. Suitable solvents can be used.

技术数据 for VH 032 amide-PEG2-alkyne

分子量 614.75
公式 C31H42N4O7S
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 2098799-80-3
PubChem ID 132045744
Smiles CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(COCCOCCOCC#C)=O)=O)O)=O)SC=N1


Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for VH 032 amide-PEG2-alkyne

参考文献 for VH 032 amide-PEG2-alkyne


Zengerle et al (2015) Selective small molecule induced degradation of the BET bromodomain protein BRD4. ACS Chem.Biol. 10 1770 PMID: 26035625

Salami et al (2017) Waste disposal-An attractive strategy for cancer therapy. Science 355 1163 PMID: 28302825

If you know of a relevant reference for VH 032 amide-PEG2-alkyne, please let us know.

关键词: VH 032 amide-PEG2-alkyne, VH 032 amide-PEG2-alkyne supplier, VH032, -, linker, 6, Proteolysis, Targeting, Chimera, PROTACs, VHL, E3, ubiquitin, ligase, PEG, conjugate, PROTAC, polyethene, glycol, von-Hippel-Lindau, protein, ligand, PEG2, VH, 032, Ligands, Plus, Linkers, 6684, Tocris Bioscience

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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia