VH 032 amide-alkylC9-acid

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Cat.No. 7404 - VH 032 amide-alkylC9-acid | C33H48N4O6S | CAS No. 2172819-78-0
说明: VHL ligand with alkyl linker and terminal acid for onward chemistry
化学名: 11-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-11-oxoundecanoic acid
纯度: ≥95% (HPLC)
文献 (1)

生物活性 for VH 032 amide-alkylC9-acid

Functionalized von-Hippel-Lindau protein (VHL) ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus an alkylC9 linker with terminal carboxylic acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines for VH 032 amide-alkylC9-acid

This product is provided for use in onward chemistry. Suitable solvents can be used.

技术数据 for VH 032 amide-alkylC9-acid

分子量 628.83
公式 C33H48N4O6S
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 2172819-78-0
PubChem ID 134184031
Smiles CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCCCCCCCCC(O)=O)=O)=O)O)=O)SC=N1


Tocris products are intended for laboratory research use only, unless stated otherwise.

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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Targeted Protein Degradation

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia