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说明： Inhibits microtubule polymerization
化学名： 4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-fluoren-9-one
纯度： ≥99% (HPLC)
生物活性 for UA 62784
UA 62784 is an inhibitor of microtubule polymerization in vitro. Interacts with tubulin dimers and promotes the accumulation of mammalian cells in apoptosis. Potentiates antiproliferative effects of vinblastine (Cat. No. 1256) in H2B-GFP HeLa cells. Originally thought to inhibit CENP-E ATPase activity.
技术数据 for UA 62784
| 分子量 | 353.37 |
| 公式 | C23H15NO3 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 313367-92-9 |
| PubChem ID | 3383533 |
| InChI Key | SVICLWPFAQYZLX-UHFFFAOYSA-N |
| Smiles | O=C2C1=CC=CC(C4=NC=C(C5=CC=C(OC)C=C5)O4)=C1C3=C2C=CC=C3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for UA 62784
参考文献 for UA 62784
参考文献是支持产品生物活性的出版物。
Tcherniuk et al (2011) UA62784 is a cytotoxic inhibitor of microtubules, not CENP-E. Chem.Biol. 18 631 PMID: 21609844
Maiato and Logarinho et al (2011) Motor-dependent and -independent roles of CENP-E at kinetochores: the cautionary tale of UA62784. Chem.Biol. 18 679 PMID: 21700202
关键词: UA 62784, UA 62784 supplier, UA62784, cytotoxic, antiproliferatives, microtubules, inhibitors, inhibits, polymerization, polymerisation, Microtubules, 4286, Tocris Bioscience
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