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Discontinued Product
4233 has been discontinued.
说明： Positive allosteric modulator of α7 nAChRs
化学名： 3a,4,5,9b-Tetrahydro-4-(1-naphthalenyl)-3H-cyclopentan[c]quinoline-8-sulfonamide
纯度： ≥98% (HPLC)
生物活性 for TQS
TQS is a type II positive allosteric modulator of α7 nACh receptors (pEC50 = 5.5). Displays no agonist activity at α7 receptors at concentrations up to 0.1 mM; potentiates agonist-evoked responses and reduces rate of desensitization of α7 nAChRs. Exhibits potency and efficacy similar to PNU 120596 (Cat. No. 2498).
技术数据 for TQS
| 分子量 | 376.47 |
| 公式 | C22H20N2O2S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 353483-92-8 |
| PubChem ID | 5038679 |
| InChI Key | SIZWDJIHABLBSP-UHFFFAOYSA-N |
| Smiles | O=S(C3=CC1=C(C=C3)NC(C4=C(C=CC=C5)C5=CC=C4)C2C1C=CC2)(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TQS
参考文献 for TQS
参考文献是支持产品生物活性的出版物。
Gronlien et al (2007) Distinct profiles of α7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes. Mol.Pharmacol. 72 715 PMID: 17565004
Gill et al (2011) Agonist activation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc.Natl.Acad.Sci. 108 5867
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关键词: TQS, TQS supplier, positive, allosteric, modulators, pam, alpha, α, a7, nicotinic, receptors, nachr, type, II, Nicotinic, (a7), Receptors, 4233, Tocris Bioscience
1 篇 TQS 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TQS 的部分引用包括：
Abbas (2017) The α7 nicotinic acetylcholine receptor positive allosteric modulator attenuates lipopolysaccharide-induced activation of hippocampal IκB and CD11b gene expression in mice. Drug Discov Ther 11 206 PMID: 28867753
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.