Thalidomide 4'-ether-PEG2-alkyne

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Cat.No. 6686 - Thalidomide 4'-ether-PEG2-alkyne | C20H20N2O7 | CAS No. 2098487-52-4
说明: Cereblon ligand with PEG linker and terminal alkyne for onward chemistry
别名: Thalidomide - linker 5
化学名: 2-(2,6-Dioxo-3-piperidinyl)-4-[2-[2-(2-propyn-1-yloxy)oxy]ethoxy]-1H-isoindole-1,3(2H)dione
纯度: ≥95% (HPLC)
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引用文献
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生物活性 for Thalidomide 4'-ether-PEG2-alkyne

Thalidomide 4'-ether-PEG2-alkyne is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus a PEG2 linker with alkyne terminal ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTACs R&D.

This product has been recently renamed. The previous name for this product was Thalidomide - linker 5

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines for Thalidomide 4'-ether-PEG2-alkyne

This product is provided for use in onward chemistry. Suitable solvents can be used.

技术数据 for Thalidomide 4'-ether-PEG2-alkyne

分子量 400.38
公式 C20H20N2O7
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 2098487-52-4
PubChem ID 131988624
InChI Key XJWGDRINRIEEJD-UHFFFAOYSA-N
Smiles O=C1N(C(C2=C(C=CC=C12)OCCOCCOCC#C)=O)C3CCC(NC3=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Thalidomide 4'-ether-PEG2-alkyne

参考文献 for Thalidomide 4'-ether-PEG2-alkyne

参考文献是支持产品生物活性的出版物。

Remillard et al (2017) Degradation of the BAF complex factor BRD9 by heterobifunctional ligands. Angew.Chem.Int.Ed.Engl. 56 5738 PMID: 28418626


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关键词: Thalidomide 4'-ether-PEG2-alkyne, Thalidomide 4'-ether-PEG2-alkyne supplier, Proteolysis, Targeting, Chimera, PROTAC, cereblon, E3, ubiquitin, ligase, PEG2-alkyne, conjugate, polyethylene, glycol, Thalidomide, -, linker, 5, Cereblon, Ligands, Plus, Linkers, 6686, Tocris Bioscience

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