Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewTH 257
说明： Potent and selective allosteric LIMK 1/2 inhibitor
化学名： N-Butyl-4-[(phenylamino)sulfonyl]-N-(phenylmethyl)benzamide
纯度： ≥98% (HPLC)
生物活性 for TH 257
TH 257 is a potent and selective allosteric LIMK 1/2 inhibitor (IC50 values are 84 and 39 nM, respectively). Inhibits cofilin phosphorylation in vitro. Exhibits no significant activity against the wider kinome.
许可信息
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the TH 257 probe summary on the SGC website.
化合物库 for TH 257
TH 257 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for TH 257
| 分子量 | 422.54 |
| 公式 | C24H26N2O3S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2244678-29-1 |
| InChI Key | VNCIWNGCMAKKEO-UHFFFAOYSA-N |
| Smiles | CCCCN(CC1=CC=CC=C1)C(=O)C1=CC=C(C=C1)[S](=O)(=O)NC1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TH 257
参考文献 for TH 257
参考文献是支持产品生物活性的出版物。
Manetti et al (2018) Recent advances in the rational design and development of LIM kinase inhibitors are not enough to enter clinical trials. Eur.J.Med.Chem. 155 445 PMID: 29908439
按产品操作查看相关产品
关键词: TH 257, TH 257 supplier, TH257, Potent, selective, LIMK1/2, LIMK1, LIMK2, inhibitors, inhibits, lim, kinases, LIMK, 6899, Tocris Bioscience
TH 257 的评论
目前没有该产品的评论。 Be the first to review TH 257 and earn rewards!
Have you used TH 257?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.