Terbinafine hydrochloride

Name: Terbinafine hydrochloride
Brand: Tocris Bioscience
SKU: 6484

Cat. No. 6484 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6484 has been discontinued.

View all Two-P Potassium Channels products.

说明： Selective K_2P9.1 (TASK-3) activator; also inhibits fungal squalene epoxidase

化学名： N-[(2E)-6,6-Dimethyl-2-hepten-4-yn-1-yl]-N-methyl-1-naphthalenemethanamine hydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献 (1)

生物活性技术数据说明书参考文献

生物活性 for Terbinafine hydrochloride

Terbinafine hydrochloride is a selective TASK3 activator (pEC₅₀ = 6.2). Exhibits >10-fold selectivity for TASK3 over TREK2, TRESK, THIK1 and TASK2. Also inhibits TWIK1 (pIC₅₀ = 5.69). Also antifungal; inhibits fungal sterol biosynthesis by inhibition of squalene epoxidase.

技术数据 for Terbinafine hydrochloride

分子量	327.89
公式	C₂₁H₂₅N.HCl
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	78628-80-5
PubChem ID	5282481
InChI Key	BWMISRWJRUSYEX-SZKNIZGXSA-N
Smiles	CN(CC1=CC=CC2=C1C=CC=C2)C/C=C/C#CC(C)(C)C.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Terbinafine hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Terbinafine hydrochloride

参考文献是支持产品生物活性的出版物。

Petranyi et al (1984) Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase. Science 224 1239 PMID: 6547247

Wright et al (2017) Terbinafine is a novel and selective activator of the two-pore domain potassium channel TASK3. Biochem.Biophys.Res.Commun. 493 444 PMID: 28882594

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关键词: Terbinafine hydrochloride, Terbinafine hydrochloride supplier, K2P, selective, TASK3, activators, activates, squalene, epoxidase, monooxygenase, inhibitors, inhibits, antifungal, antimycotic, Two-P, Potassium, Channels, Other, Oxygenases/Oxidases, Antifungals, 6484, Tocris Bioscience

1 篇 Terbinafine hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Terbinafine hydrochloride 的部分引用包括：

Richard L et al (2021) Modulation of TASK-1/3 channels at the hypoglossal motoneuron pool and effects on tongue motor output and responses to excitatory inputs in vivo: implications for strategies for obstructive sleep apnea pharmacotherapy. Sleep 44 PMID: 32745213