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Submit ReviewTC-P 262
说明： Selective P2X3 and P2X2/3 antagonist
化学名： 5-[5-Methyl-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine
纯度： ≥99% (HPLC)
生物活性 for TC-P 262
TC-P 262 is a selective P2X3 and P2X2/3 receptor antagonist (pIC50 values are 7.39 and 6.68 respectively). Displays no detectable activity at P2X1, P2X2, P2X4 and P2X7 receptors (pIC50 < 4.7).
技术数据 for TC-P 262
| 分子量 | 258.32 |
| 公式 | C14H18N4O |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 873398-67-5 |
| PubChem ID | 59598765 |
| InChI Key | RAKSAPLZNJXYRB-UHFFFAOYSA-N |
| Smiles | NC1=NC(N)=NC=C1OC2=C(C(C)C)C=CC(C)=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TC-P 262
参考文献 for TC-P 262
参考文献是支持产品生物活性的出版物。
Ballini et al (2011) Characterization of three diaminopyrimidines as potent and selective antagonists of P2X3 and P2X2/3 receptors with in vivo efficacy in a pain model. Br.J.Pharmacol. 163 1315 PMID: 21410458
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关键词: TC-P 262, TC-P 262 supplier, Selective, P2X3, P2X2/3, receptors, antagonists, TC-P262, P2X, Receptors, 4386, Tocris Bioscience
1 篇 TC-P 262 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TC-P 262 的部分引用包括：
Hui et al (2020) Simultaneous Control of Endogenous and User-Defined Genetic Pathways Using Unique ecDHFR Pharmacological Chaperones. Cell Chem Biol 27 622-634.e6 PMID: 32330442
TC-P 262 的评论
平均评分: 4 (Based on 1 Review.)
Have you used TC-P 262?
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Itch behavior.
By
jialie luo on 01/10/2018
分析类型： In Vivo
种属： Mouse
TC-P 262 was used to test itch response
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.